异甘草酸镁治疗化疗药物性肝损害的临床疗效观察  

Clinical effects of isoglycyrrhizinate on hepatic dysfunction induced by chemotherapeutic drugs

作　　者：李志宏[1] 郝磊[2] 孔佩艳[2] 李杰平[2] 曾东风[2] 刘红[2] 秦先念[2] 

机构地区：[1]山西省中医院,山西太原030012 [2]第三军医大学新桥医院血液科,重庆400037

出　　处：《实用临床医药杂志》2011年第1期88-89,共2页Journal of Clinical Medicine in Practice

摘　　要：目的观察异甘草酸镁治疗化疗药物所致肝损害的临床疗效。方法 108例化疗患者随机分为治疗组63例和对照组45例,在预防性保肝药物基础上,治疗组予异甘草酸镁0.15 g,对照组予硫普罗宁0.2 g,静脉滴注1次/天,直到转氨酶降至正常。每3天复查1次肝功能,对比9 d内谷丙转氨酶(ALT)、谷草转氨酶(AST)的复常率。结果治疗组9 d内ALT复常率为95.83%,AST复常率为92.42%;对照组ALT复常率为74.23%,AST复常率为71.12%,两组比较差异有统计学意义(P<0.01)。两组均未出现严重的不良反应。结论异甘草酸镁治疗化疗药物性肝损害具有肝功恢复快、不良反应少的优点,临床疗效优于硫普罗宁。Objective To observe the clinical effects of isoglycyrrhizinate as preventive hepatoprotective drugs on chemotherapy-induced hepatic dysfunction.Methods A randomized controlled study was established.0.15 g isoglycyrrhizinate or 0.2 g tiopronin was given once per day intravenously in the treatment group（63 cases） and control group（45 cases）,respectively in addition to receiving preventive hepatoprotective drugs until transaminase restored to the normal level.The liver function was checked on day 3,6 and 9 days post drug administration.Recovery rates of ALT and AST were compared between the treatment group and the control group.Results ALT in 95.83% patients in the treatment group restored to the normal,significantly different with the control group（74.23%）.The recovery rate of AST in the treatment group was 92.42%,significantly higher than that in the control group（71.12 %）.There was no serious adverse reaction that affected therapy in the two groups.Conclusion Addition of isoglycyrrhizinate has major advantages in the treatment of chemotherapeutic drug-induced hepatic dysfunction including rapid recovery of liver function and less adverse reaction.

关 键 词：异甘草酸镁 化疗药物 肝损害 

分 类 号：R512.6[医药卫生—内科学]