Akt/PKB抗凋亡机制与天然活性物质的抗肿瘤作用  

The anti-apoptosis mechanisms of Akt/PKB and anti-tumor effects of natural active substances

作　　者：刘玉梅[1] 祖桂芳[2] 赵晓红[1] 梅晶[1] 

机构地区：[1]北京联合大学应用文理学院,北京100191 [2]首都师范大学生物科学学院,北京100037

出　　处：《生命科学》2011年第1期1-6,共6页Chinese Bulletin of Life Sciences

基　　金：北京市自然科学基金项目(7092015)

摘　　要：Akt/PKB是调控细胞生存与凋亡的重要信号物质之一。它能够影响下游多种效应分子的活化状态,在细胞内发挥着抑制细胞凋亡、促进细胞增殖的作用,并同人类多种肿瘤的发生发展密切相关。天然活性物质能够通过抑制Akt/PKB通路、诱导细胞凋亡来发挥它们的抗肿瘤效应。对Akt/PKB与细胞凋亡关系的研究不但有利于理解细胞凋亡机制,还可以指导开发新型的抗癌活性物质。本文综述了Akt/PKB对细胞凋亡、存活的调节机制及天然活性物质通过PI3K/Akt信号通路抗肿瘤作用的研究进展。Akt/PKB is one of the important signal molecules,which play a pivotal role in inhibiting apoptosis,promoting proliferation and influencing the activation state of some downstream molecules,and is closely correlated with human tumorigenesis.The anti-tumor effects of natural active substances can be achieved by inhibiting Akt signaling pathway to induce apoptosis.The study of the relationship between Akt/PKB and apoptosis is important,not only for understanding the basic cellular life phenomenon,but also for developing new anticancer active compounds.The mechanisms of Akt/PKB regulation in apoptosis,cell survival and anticancer effects of natural active substances by Akt/PKB signaling pathway were reviewed.

关 键 词：AKT/PKB 细胞凋亡 信号通路 抗肿瘤 天然活性物质 

分 类 号：Q71[生物学—分子生物学]