糖尿病下肢血管病变与血浆内脏脂肪素的关系  

A relationship between lower limb vascular disease and plasma visfatin in patients with T2DM

作　　者：黄东辉[1] 郭征东[2] 唐先格[2] 孙田歌[2] 

机构地区：[1]泰山医学院临床学院,山东泰安271000 [2]泰山医学院附属医院内分泌科

出　　处：《中国糖尿病杂志》2011年第2期112-115,117-119,共4页Chinese Journal of Diabetes

摘　　要：目的研究2型糖尿病(T2DM)患者不同程度的下肢血管病变与血浆内脏脂肪素的关系。方法选择泰安地区的T2DM患者112例,根据临床症状和下肢动脉彩色多普勒超声情况,分为单纯T2DM组42例,糖尿病合并轻度下肢动脉硬化(T2DM-MLAD)组38例和糖尿病合并重度下肢动脉硬化(T2DM-SLAD)组32例,另选取正常对照(NC)组40名。测定内脏脂肪素和其他相关临床指标,进行数据统计。结果 NC组与单纯T2DM组相比内脏脂肪素无统计学差异[分别(46.79±7.67)和(50.86±11.65)ng/ml,P>0.05],T2DM-MLAD组和T2DM-SLAD组内脏脂肪素[分别(58.75±13.52)和(67.21±16.6)ng/ml]均明显高于NC组和单纯T2DM组(P<0.01),T2DM-SLAD组又明显高于T2DM-MLAD组(P<0.01)。Pearson相关分析表明,内脏脂肪素与WHR、FIns、HOMA-IR、下肢血管内膜中层厚度(IMT)、HbA_1c呈正相关。踝肱指数(ABI)随糖尿病下肢动脉病变的出现与加重而逐渐降低。结论内脏脂肪素与T2DM患者下肢血管病变程度明显相关,是下肢动脉硬化的危险因素。Objective To study the relationship of the lowerlimb vascular disease with plasma visfatin in diabetics. Methods The study subjects included T2DM patients with mild lower limb atherosclerosis （n=38, T2DM-MLAD）, with severe LA （n = 32, T2DM SLAD）, without LA （n= 42, T2DM） and healthy control （n = 40, NC）. ABI, serum visfatin, IMT of lower limbs by ultrosound and general clinical data were determined. Results Serum visfatin showed a similar level [（46.79±7. 7）vs （50.86 ± 11.65） ng/ml, P〉 0. 051 between NC and T2DM groups, and a gradually lower levels from T2DM-SLAD to T2DM-MLAD to T2DM groups[（67.21±16.67）vs（58.75±13.52）vs（50.86± 11.65） ng/ml respectively, intergroup comparison： all〈0. 05]. Serum visfatin was positively correlated with IMT of lower limbs, IR,HbA1c,FIns and WHR. Conclusion Serum visfatin is a risk factor for lower limb atherosclerosis and positively correlated with severity of lower limb atherosclerosis. Ankle-brachial index is decreasing along with the progressing of lower limb atherosclerosis.

关 键 词：糖尿病 2型 下肢血管病变 内脏脂肪素 内膜中层厚度 下肢动脉 

分 类 号：R587.1[医药卫生—内分泌]