药物静脉自身给药发展和药物强化作用认同的历史沿革  

Implantable fluorouracil sustained release treatment of gastrointestinal cancer care

作　　者：吕秀依[1] 翟海峰[2] 马宝苗[1,3] 刘昱[1] 

机构地区：[1]宁波大学医学院,宁波315211 [2]北京大学中国药物依赖性研究所,北京100191 [3]江汉大学武汉生物医学研究院,武汉430567

出　　处：《中国药物依赖性杂志》2011年第1期1-4,共4页Chinese Journal of Drug Dependence

基　　金：浙江省自然基金(Y2091155);国家自然科学基金(30873051)

摘　　要：药物成瘾研究中通常使用的动物模型包括药物辨别、自发活动行为敏化、条件性位置偏爱和自身给药。不同的动物模型可以从不同角度研究成瘾性药物的多种作用,既有相似点,也有很大的区别。其中,自身给药是最能反映人类主动觅药和用药行为的动物模型,使客观考察药物成瘾者的主动强迫性用药这一行为特点成为可能,从而在药物成瘾研究中得到广泛的应用[1]。纵观自身给药模型的发展,也恰好反映了学术界对成瘾性药物本身强化作用的早期争论和最终认同。因此,这篇文章将着重阐述药物静脉自身给药模型的发展以及药物强化作用在自身给药行为中角色认同的历史沿革。Objective To investigate the care of patients with gastrointestinal cancer treat of sustained release implant fluorouracil.Methods Nursing intervention in 81 cases of gastrointestinal cancer patients with peritoneal implantation sustained release fluorouracil for regional chemotherapy.Results One wound liquefaction occured in 81 cases of surgery after implantation of sustained release fluorouracil,and the remaining incisions healed well,no anastomotic leakage,peritonitis and intestinal obstruction appear.The average hospital stay was 11 days.There were no deaths,no postoperative follow-up abdominal and liver metastases.Conclusion Peritoneal implantation of sustained-release agents fluorouracil in the gastrointestinal malignant tumors can improve the efficacy of regional chemotherapy,and it has no obvious side effects,and it is an effective way of prevention of postoperative recurrence and metastasis.consummate care is an important part of successful treatment.

关 键 词：静脉自身给药 药物辨别 强化作用 药物成瘾者 条件性位置偏爱 动物模型 成瘾性药物 自身给药行为 

分 类 号：R971[医药卫生—药品]