吗啡依赖自然戒断后大鼠造抑郁样模型探讨  

THE DEPRESSIVE BEHAVIOR OF RATS AFTER MORPHINE WITHDRAWAL

作　　者：方圆[1] 高峻钰[1] 

机构地区：[1]军事医学科学院附属医院戒毒科,北京100071

出　　处：《中国药物依赖性杂志》2011年第1期26-29,共4页Chinese Journal of Drug Dependence

摘　　要：目的:观察吗啡依赖大鼠自然戒断后行为学表现,初步探讨戒断后能否导致抑郁行为的发生以及抑郁样行为的变化。方法:选取敞箱测试和基础蔗糖水测试相接近的大鼠30只,随机分为吗啡给药组和生理盐水对照组,采用腹腔注射(ip)给药7 d建立吗啡依赖大鼠模型,分别用敞箱、蔗糖水偏爱测试评价戒断d3和d9的行为学表现。结果:吗啡依赖大鼠在戒断期间饮食量下降,体重先下降后缓慢增加,在戒断d3,敞箱活动总路程、垂直运动得分下降,蔗糖水饮用减少(P<0.05);在戒断d9,敞箱中活动总路程、垂直运动得分、蔗糖水饮用较正常组下降,两组间无明显统计学差异。结论:吗啡依赖戒断能导致大鼠抑郁样行为发生,这种状态随着戒断时间的延长而逐渐消失。Objective：To observe the behaviors of rats after morphine withdrawal,and see if withdrawal could lead to depressive-like behaviors and how they developed.Methods：Thirty Wistar rats with basic test result alike were chosen and randomly divided into morphine treatment group（Mor group） and saline treatment group（NS group）.After the rats were intraperitoneally administrated morphine and saline,respectively for 7 days,we observed their behaviors on the third and ninth day after withdrawal in the following tests：the open field test,the sucrose preference test.Results：Rats withdrawal from morphine had somatic withdrawal symptoms and depressive-like behaviors.On day 3 after morphine withdrawal,the total distances and scores rearing and percentage of sucrose consumption decreased（P〈0.05）.On day 9 after morphine withdrawal,no significant statistical differences in the open field test or in the sucrose preference test were observed.Conclusion：Withdrawal after morphine can lead to depressive-like behaviors and the depressive-like behaviors may disappear as time goes on.

关 键 词：吗啡 抑郁 行为学 

分 类 号：R965[医药卫生—药理学]