黄芩苷柔性纳米脂质体的制备  

Preparation of Baicalin Flexible nano-Liposomes

作　　者：陈燕军[1] 贾燕[1] 金日显[1] 顼佳音[1] 熊欣[1,2] 袁军林[1] 刘淑芝[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]江西中医学院,南昌330006

出　　处：《中国实验方剂学杂志》2011年第5期1-4,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部"重大新药创制"科技重大专项(2009ZX09502-010)

摘　　要：目的:制备黄芩苷柔性纳米脂质体。方法:采用薄膜分散法制备柔性纳米脂质体混悬液,以黄芩苷的含量作为工艺研究中包封率的评价指标,以粒径、粒径分散系数,Zeta电位及包封率为考察指标,采用正交试验筛选最佳处方和制备工艺条件,并考察其物理化学性质。结果:最佳处方和制备工艺条件为卵磷脂与胆酸钠的质量比6∶1,卵磷脂与黄芩苷的质量比10∶1,探头超声时间15 min。包封率60.11%,所得的柔性纳米脂质体为类球形实体粒子,平均粒径175 nm,平均Zeta电位-78.9 mV。结论:黄芩苷柔性纳米脂质体处方和制备工艺基本可行。Objective：To prepare baicalin flexible nano-liposomes. Method： By film dispersion method to prepare flexible nano liposome suspension to the content of baicalin in encapsulation efficiency as the technology of the evaluation index, particle size, particle size dispersion coefficient, Zeta potential and entrapment efficiency of the indexes, the best prescription by orthogonal test and the preparation conditions, and studied its physical and chemical properties. Result ： The best prescription and conditions for the preparation of lecithin and sodium cholate mass ratio of 6： 1, lecithin and baicalin is a 10：1 ratio, ultrasonic probe time is 15min. The encapsulation efficiency was 60. 11% ,from the flexible nano-liposomes are spherical solid particles,average particle size of 175 nm,the average Zeta potential was -78.9 mV. Conclusion： Baicalin flexible nano-liposomes formulation and preparation process are basically feasible.

关 键 词：黄芩苷 柔性纳米脂质体 薄膜分散法 

分 类 号：R283.6[医药卫生—中药学]