大黄黄连泻心汤、理中丸对幽门结扎型及醋酸涂抹型胃溃疡寒、热证大鼠模型的药效学比较研究  

Comparative Study of Dahuang Huanglian Xiexin Decoction,Lizhong Pill on Pharmacodynamics for Gastric Ulcer with Cold or Heat Syndrome Induced by Pylorus Deligation or Smearing Acetic Acid in Rats

作　　者：柴剑波[1] 李冀[1] 毕珺辉[1] 于海[1] 赵伟国[1] 蒋蕾[1] 谢田[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《中国实验方剂学杂志》2011年第5期134-136,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金："十一五"国家科技支撑计划项目(2006BAI08B04-03)

摘　　要：目的:探讨寒、热方剂对幽门结扎型、醋酸涂抹型胃溃疡寒热证模型大鼠溃疡指数的影响,从药效学角度验证模型的可行性,并阐明其方证相应的客观规律。方法:采用"寒、热因素"分别结合幽门结扎、醋酸涂抹法,建立大鼠胃溃疡寒、热证模型,分别予大黄黄连泻心汤(1.8 g.kg-1)和理中丸(3.6 g.kg-1)ig,连续4 d测定其溃疡指数。结果:病证结合模型组溃疡指数皆明显高于单纯病模型组(P<0.01)。大黄黄连泻心汤治疗组及理中丸治疗组与病证结合模型组比较溃疡指数显著下降(P<0.05或P<0.01)。且寒性方剂大黄黄连泻心汤对于热模型的治疗作用明显优于热性方剂理中丸;热性方剂理中丸对于寒模型的治疗作用明显优于寒性方剂大黄黄连泻心汤(P<0.05)。结论:大黄黄连泻心汤对热模型胃黏膜损伤有显著的防治作用;理中丸对寒模型发挥了明显的防治作用,有效降低其溃疡指数,体现了一定的方证相应规律。Objective：To explore the influence of the cold or heat prescription on ulcer with cold or heat syndrome in gastric ulcer model rats induced by pylorus deligation or smearing acetic. Then to verify the feasibility of this model from the point of pharmacodynamics, and to elucidate the objective regularity of ＇ formula-syndzome corresponding＇. Method：Adopting cold or heat factors combined with pylorus deligation or smearing acetic acid methods,gastric ulcer model combined with cold and heat syndrome was established. Then the ulcer indexes were ob- served. Result：The ulcer indexes of＇ disease-syndrome combination model group＇ are all higher than the ＇simple disease model group＇ obviously,and the differences are significant（P 〈 0.01 ）. Compared to the ＇disease-syndrome combination model groups＇ ,the ulcer indexes decreased in Dahuang Huanglian Xiexin Decoction therapeutic group or Lizhong Pill therapeutic group remarkably （ P 〈 0.05 or P 〈 0.01 ）. The therapeutic action of cold prescription Dahuang Huanglian Xiexin Decoction on heat model is superior to heat prescription Lizhong Pill. The therapeutic action of heat prescription Lizhong Pill on cold model is superior to cold prescription Dahuang Huanglian Xiexin Decoction, （ P 〈 0.05 ）. Conclusion ： Dahuang Huanglian Xiexin Decoction has conspicuous preventive and therapeutic effects. Lizhong Pill performs remarkable preventive and therapeutic effects. They both can decrease the ulcer indexes for corresponding model,indicating certain objective regularityof ＇ formula-syndrome corresponding＇.

关 键 词：幽门结扎 醋酸 胃溃疡 寒热证 药效学 

分 类 号：R285.5[医药卫生—中药学]