淫羊藿女贞子对激素干预撤停阶段大鼠哮喘模型HPA轴及骨代谢的影响  

Study of Effects of Combination of Herba Epimedii,Fructus Ligustrilucidi and Dexamethasone on HPA axis and Bone Metabolism of Asthmatic Model in Rats

作　　者：刘仁慧[1] 杨婧[1] 王培[1] 潘凉[1] 王秀娟[1] 

机构地区：[1]首都医科大学中医药学院.北京100069

出　　处：《中国实验方剂学杂志》2011年第5期137-139,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30801494);北京市优秀人才项目(20081D0501800209)

摘　　要：目的:探索淫羊藿女贞子配伍对哮喘模型大鼠激素撤停阶段下丘脑-垂体-肾上腺(HPA)轴及骨代谢的影响。方法:比较各组血清皮质醇(COR),及骨钙素(BGP),血浆促肾上腺皮质激素(ACTH),下丘脑促肾上腺皮质激素释放激素(CRH)含量的差异。结果:与激素干预哮喘模型组比较,淫羊藿女贞子合激素干预Ⅰ,Ⅱ组血浆ACTH含量显著降低,下丘脑CRH含量无明显差异;淫羊藿女贞子合激素干预Ⅱ组血清BGP,COR含量显著升高。结论:淫羊藿女贞子对激素干预哮喘模型有改善糖皮质激素(GC)类药物对内源性GC的抑制作用,改善骨代谢。Objective：To observe the effects of the combination of Herba Epimedii, Fructus Ligustrilucidi and dexamethasone on hypothalamic-pituitary-adrenocortical（HPA） axis and bone metabolism of asthmatic model in rats during withdrawal stage. Method ： The following indexes, including the content of serum COR, plasma ACTH, hypo- thalamic CRH and plasma BGP,were observed. Result ：ACTH content of group I and Ⅱ of the combination of Herba Epimedii, Fructus Ligustrilucidi and GC （ YN and GC group I , Ⅱ ） were significantly lower（ P 〈 0.05 and 0.01, respectively） , YN and GC group Ⅱ had a significant difference for the level of COR and BGP（ all P 〈 0.05） ,compared with the GC group. Conclusion：The combination of Herba Epimedii, Fructus Ligustrilucidi has the adjustment effects of the inhibition of dexamethasone to the HPA axis and bone metabolism in asthma treatment.

关 键 词：哮喘 淫羊藿/女贞子 HPA轴 骨钙素 

分 类 号：R285.5[医药卫生—中药学]