黄芪不同有效部位对糖尿病模型大鼠血清胰岛素、脂联素的影响  

Effect of Astragali Radix Active Ingredients on Serum Insulin and Adiponectin in Diabetes Rats

作　　者：李楠[1] 范颖[1] 贾旭鸣[1] 马哲[1] 林庶茹[2] 

机构地区：[1]辽宁中医药大学方剂学科,沈阳110032 [2]辽宁中医药大学中医分子生物实验室,沈阳110032

出　　处：《中国实验方剂学杂志》2011年第5期144-146,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30873232)

摘　　要：目的:探讨黄芪黄酮、黄芪多糖、黄芪皂苷3种有效部位对糖尿病大鼠血糖、血清胰岛素和脂联素的影响。方法:按STZ 52 mg.kg-1体重腹腔注射SD大鼠诱导糖尿病模型,分别给予黄芪黄酮、黄芪多糖、黄芪皂苷进行干预,给药剂量均相当于黄芪生药量6.3 g.kg-1。观测30 d,血糖仪检测血糖,ELISA法检测血清胰岛素、血清脂联素。结果:糖尿病模型大鼠血糖水平升高(P<0.05),血清胰岛素、脂联素水平下降(P<0.05)。黄芪黄酮可明显干预上述变化(P<0.05);黄芪多糖与黄芪皂苷虽略改善糖尿病模型大鼠的血糖、血清胰岛素、血清脂联素的水平,但未见统计学差异。结论:黄芪有效部位可影响糖尿病模型大鼠血糖、血清胰岛素和脂联素水平的变化,黄芪黄酮作用最为显著。Objective：This study was designed to evaluate the effect of three active ingredients of Astragali Radix,namely a Astragalus flavonoids,polysaccharides,and astragalosides,on blood glucose,serum insulin and adi-ponectin in diabetes rats.Method：Diabetes rats were induced by STZ（52 mg.kg-1,peritioneal injection）.The rats were grouped for administrating with astragalus flavonoids,polysaccharides,and astragalosides accordingly for 4 weeks,then detection of blood glucose and ELISA assay of serum insulin and adiponectin were done.Result：The blood glucose of diabetes rats ascended（P 〈 0.05）,serum insulin and adiponectin descended（P 〈 0.05）,all of these changes were antagonised in various degrees by astragalus flavonoids,polysaccharides and astragalosides,spe-cially,the effect of astragalus flavonoids was obvious（P 〈 0.05）.Conclusion：The three active ingredients of Astrag-alus Radix could influence the content of blood glucose,serum insulin and adiponectin in diabetes rats,the best one was astragalus flavonoids.

关 键 词：黄芪有效部位 糖尿病模型 血糖 胰岛素 脂联素 

分 类 号：R285.5[医药卫生—中药学]