鼻腔冲洗联合布地奈德雾化吸入治疗婴幼儿变应性鼻炎的疗效观察  

The curative effect of nasal flush combined budesonide suspension liquid atomizing inhaled treatment in in-fant allergic rhinitis

作　　者：孙晓卫[1] 高玉芳[1] 巩克波[1] 窦芬芬[1] 张子和[1] 张建基[1] 

机构地区：[1]山东大学齐鲁儿童医院耳鼻喉科,山东省济南250022

出　　处：《中国基层医药》2011年第3期313-314,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察鼻腔冲洗联合布地奈德混悬液雾化吸入治疗婴幼儿变应性鼻炎的疗效。方法收集137例变应性鼻炎患儿，随机分为治疗组70例和对照组67例进行治疗。对照组依次使用2．8％温氯化钠溶液50ml和0．5％甲硝唑注射液30m1冲洗鼻腔，初始1周，1次／d，后1周隔日1次，同时根据年龄、体质量12I服氯雷他啶，1次／d。治疗组在对照组基础上加用布地奈德混悬液1ml经鼻雾化吸入。治疗结束后比较两组临床疗效。结果治疗组70％的患儿鼻塞、喷嚏、流清涕于3次治疗后即出现明显减轻，伴睡眠打鼾患儿睡眠质量明显改善，夜间翻身次数减少；对照组56．7％的患儿以上症状改善；疗程结束后评价治疗组有效率为95．1％，对照组有效率为77．7％，差异有统计学意义（X^2=9．83，P〈0．01），137例患儿无一例发生不良反应。结论鼻腔冲洗联合布地奈德混悬液经鼻雾化吸入治疗婴幼儿变应性鼻炎疗效显著，起效迅速，安全。Objective To observe the nasal flush combined budesonide suspension liquid atomizing inhaled treatment of allergic rhinitis in infants, explore the allergic rhinitis treatments in infants. Methods 137 cases diagnosed as allergic rhinitis were collected and randomly divided into 70 cases as the treatment group and 67 patients as the control group. The patients in control group were washed the nasal cavity with 2.8% warm sodium chloride solution using 50ml and 0.5% metronidazole injection 30ml by turn. At the first week, 1 time/d, then one time every other day,while according to age, body mass the patients were given to loratadine, 1 time/d. Treatment group were used budesonide nasal inhalation of 1 ml at the base of treatment of the control group. Before and after the treatment , nasal congestion,sneezing, flow clear nose, sleep snoring and sleep quality score index were observed and compared. Results 70% of the treatment group the nasal congestion, sneezing, flow clear in 3 times after treatment with ease. The children sleep quality improved and the snoring fewer over night, only 56.7% of the control group of these symp- toms improved. After the treatment the efficiency evaluation of treatment group and control group respectively was 95.1% and 77.7%, there was statistically significant difference （ X^2 = 9.83,P 〈 0.01 ）. 137 cases of patients without a side effects. Conclusion curative effect of nasal flush combined budesonide suspension hquid nasal spray inhaled treatment of allergic rhinitis was distinct,infant effect-acting quickly, without side effects, easy to use.

关 键 词：鼻腔冲洗 布地奈德 婴幼儿 变应性鼻炎 

分 类 号：R76[医药卫生—耳鼻咽喉科]