^(18)F正电子药物自动化合成装置BNU F-A2的研制及应用  

DEVELOPMENT AND APPLICATION OF AUTOSYNTHESIZERS BNU F-A2 FOR RADIOPHARMACEUTICALS LABELED WITH ^(18)F

作　　者：乔洪文[1,2] 李崧[1,3] 刘亚静[1,2] 浮吉生[1,2] 刘正浩[1] 孙继壮[1] 朱霖[1,2] 

机构地区：[1]北京师范大学放射性药物工程中心 [2]放射性药物教育部重点实验室,北京师范大学化学学院 [3]北京师范大学分析测试中心,北京100875

出　　处：《北京师范大学学报（自然科学版）》2011年第1期49-53,共5页Journal of Beijing Normal University(Natural Science)

基　　金：国家"973"资助项目(2006CB500705);国家"863"计划资助项目(2006AA02Z184)

摘　　要：为满足北京日益增长的新型18F药物研究和应用的需要,研制多功能的自动化合成装置迫在眉睫.BNU F-A2型自动化合成装置是北京师范大学研制、以"多功能"和"自动化"为设计原则、一款用于自动化合成18F-放射性药物的装置.该装置可一次加载9种溶液,通过夹管式电磁阀控制流动,反应温度可在当前室温至最高150℃的范围内任意设定,满足单步、多步法18F药物标记及纯化的需要;装置控制程序采用模块化设计,将反应流程划分为若干步骤,通过在每步中设定装置动作和反应条件,完成相应的实验操作流程.装置可通过手动、无线遥控和工作站3种方式操作,以全自动和步进2种方式运行,这样可减少对操作人员的辐射损伤、更好地保护操作人员.应用该装置,自动化合成了乏氧组织显像药物[18F]FMISO和[18F]FET.结果表明:BNU F-A2型合成装置硬件结构设计灵活、控制程序友好、操作简单,满足了新型18F药物研究的需要,正在成为新型18F标记正电子药物研究的有力工具.BNU F-A2,an auto-synthesizer,for radiopharmaceutical labelling with 18F,has been developed,which can implement multiple chemical processes such as drying,fluoridation,purification,and can be used to synthesize multiple radiopharmaceuticals labeled with 18F.Compared with already commercialized auto-synthesizers,BNU F-A2 is multifunctional,more appropriate and inexpensive for use in research.For hardware,up to 9 solutions can be loaded in separate vials,and be controlled by solenoid valves.Reaction time and temperature can be setup with a large range.For software,modular programming is used to separate the chemical processes into serial steps.The auto-synthesizer can be controlled manually,be wireless controlled,or operated by a workstation either automatically or step-by-step.FMISO and FET were synthesized using this auto-synthesizer.Such pilot studies indicated that BNU F-A2 was flexible hardwarewise,and friendly softwarewise.It is a powerful and efficient instrument for research and exploitation of radiopharmaceuticals.

关 键 词：自动化合成装置 18F 正电子药物 多功能性 自动化 

分 类 号：O572.2[理学—粒子物理与原子核物理]