1,6-二磷酸果糖后处理对心脏瓣膜置换术患者围术期炎性反应的影响  

Effect of fructose-1,6-diphosphete postconditioning on systemic inflammation in perioperative patients undergoing cardiac valve replacement

作　　者：杨东林[1] 王建斌[1] 冉珂[1] 王丹[1] 常业恬[1] 

机构地区：[1]中南大学湘雅二医院麻醉科,长沙410011

出　　处：《中南药学》2011年第1期72-74,共3页Central South Pharmacy

基　　金：湖南省科技厅项目(2009JT3018)

摘　　要：目的观察1,6-二磷酸果糖(FDP)后处理对心脏瓣膜置换术患者围术期炎性反应的影响。方法 30例择期心脏瓣膜置换术患者随机分为1,6-二磷酸果糖后处理组(F组)和对照组(C组),每组15例。于主动脉开放即刻从体外循环机内F组加入250 mg.kg-1的FDP,C组加入等容积的生理盐水。于切皮即刻(T1),主动脉开放后0.5 h(T2)、3 h(T3)、24 h(T4)测白细胞介素6(IL-6)、白细胞介素10(IL-10)和肌钙蛋白I(cTnI)。结果与C组比较,F组IL-6和cTnI含量明显降低(P<0.05),IL-10明显升高(P<0.05)。结论 FDP后处理通过抑制缺血-再灌注后的炎性反应对心肌产生保护作用。Objective To study the protective effect of fructose-1,6-diphosphete（FDP） on myocardial ischemia-reperfusion injury in patients undergoing valve replacement.Methods A total of 30 patients were randomly divided into a control group（group C） and an FDP group（group F）,15 in each group.FDP 250 mg·kg-1 was infused from the cardiopulmonary bypass machine just on the time of arteriae aorta opening in group F,while physiologic saline with the same volume was given instead of FDP in group C.Blood samples were taken to determine the concentration of IL-6,IL-10 and cTnI immediately after the skin incision（T1）,at aortic opening of 0.5 h（T2）,3 h（T3）,and 24 h（T4）.Results The concentrations of IL-6 and cTnI in the FDP group were significantly lower than those in the control group at T2,T3,and T4 and the concentrations of IL-10 in the FDP group were significantly higher than those in the control group.Conclusion FDP postconditioning can ameliorate myocardial ischemia reperfusion injury by modulate inflammatory response.

关 键 词：1 6-二磷酸果糖 心脏瓣膜置换 后处理 炎症 

分 类 号：R977.7[医药卫生—药品]