注射吸毒人群HCV感染相关因素的分析  

Correlated Factors of Hepatitis C Virus Infection among Injection Drug Users

作　　者：龚建明[1] 李雷[2] 王昊鹏[2] 唐卫明[3] 羊海涛[3] 张云[3] 

机构地区：[1]南京军区联勤部门诊部,江苏南京210002 [2]江苏省疾病预防控制中心性病艾滋病防治科,江苏南京210009 [3]南京军区军事医学研究所,江苏南京210002

出　　处：《药物生物技术》2011年第1期61-65,共5页Pharmaceutical Biotechnology

基　　金：国家自然科学基金资助项目(30972628)

摘　　要：为了探讨注射吸毒人群丙型肝炎病毒（HCV）感染的影响因素,以2006~2008年江苏省5市部分戒毒所、劳教所新入的1 358例注射吸毒人员为调查对象。对调查对象进行问卷调查,采血并对血液标本行ELISA法检测抗-HCV,数据用SPSS13.0行单因素和多因素分析。1 358例注射吸毒者中共检测出HCV抗体阳性者798例,阳性率为58.8%;男性注射吸毒者易感染HCV（χ2=8.30,P〈0.05）;随着年龄的增长HCV的感染率呈下降趋势（χ2=11.87,P〈0.05）;共用注射器、注射吸毒时间大于10年、商业性性行为是该人群HCV感染的危险因素。注射吸毒人群中HCV感染率远高于一般人群,说明该人群是HCV防治重点人群。因此,对该人群HCV感染的危险因素需进行针对的健康教育和行为干预综合防治措施。The purpose is to explore the correlated factors of hepatitis C virus infection among injection drug users（IDUs）.A total of 1358 IDUs were surveyed,who were newly locked up during April to June in 2006~2008 at 5 sentinel sites,which were established as parts of detoxification centers and reeducation centers of Jiangsu Province.Besides the questionnaires survey,intravenous blood samples were also taken for HCV antibody test with ELASA.Univariate and multivariate analysis were performed by SPSS13.0 based on cleaned data.Among 1358 IDUs,798 were HCV positive cases,with the rate being 58.8%.Compared with female,male are more tend to infect HCV（χ2=8.30,P0.05）.Also the younger IDUs have more opportunities to get HCV（χ2=11.87,P0.05）.Syringe sharing,more than 10 years of injecting drug use and commercial sexual behavior were correlated to HCV infection.The positive rate of HCV infection among IDUs was greatly higher than that of the general people,which tells us that a great attention should be paid to them.Furthermore,more targeted health education,behavioral intervention integrated prevention and control measures should be taken immediately.

关 键 词：注射吸毒 丙型肝炎病毒 多因素分析 

分 类 号：R512.63[医药卫生—内科学]