P40家族成员及其在自身免疫性疾病中的作用  

Role of P40 Family Member in Autoimmune Diseases

作　　者：郭薇[1] 朱玥[1] 罗成[1] 王辰[1] 姚文兵[1] 

机构地区：[1]中国药科大学生命科学与技术学院分子生物学教研室,江苏南京210009

出　　处：《药物生物技术》2011年第1期81-84,共4页Pharmaceutical Biotechnology

摘　　要：作为P40家族中研究最为广泛的细胞因子,白细胞介素-12(Interleukin-12)其最显著的特点是有助于Th1细胞分化,参与由Th1细胞所介导的免疫性疾病。而白细胞介素-23(Interleukin-23)与Th17细胞增殖有关,最新发现Th17介导的免疫反应在实验性变态反应性脑脊髓炎(EAE)和多发性硬化症(MS)疾病方面发挥重要作用,并且其分化途径的提出对传统的Th1/Th2细胞免疫也带来了新的挑战[1]。该家族的另外两个成员P40单体和P40同源二聚体也参与免疫调控,实验证明P40分子不仅在细胞内感染及炎症过程中起着重要的调节作用,而且与银屑病、多发性硬化症、Crohn's病等多种自身免疫性临床疾病的发病密切相关。The IL-12,the most widely studied cytokine of this family,is well-characterized for its Th1-favoring activity,and therefore plays a key role in the pathophysiology of Th1-mediated autoimmune diseases.On the other hand,the IL-23,another member of the P40 family with shared P40 subunit,drives polarization of Th17,a subset of T cell suspected to have a key role in the pathophysiology of MS and experimental allergic encephalomyelitis（EAE）,poses a challenge to our current understanding of Th1/Th2 hypotheses in autoimmune diseases.However,the more puzzling issues are the biological roles of other two members of this family,the P40 monomer and the P402,the homodimer.Both P402 and P40 appear to have a proinflammatory role.The current review focuses on biological function of P40 family of cytokines with particular emphasis on autoimmune diseases.

关 键 词：P40亚基 白细胞介素-12 白细胞介素-23 自身免疫性疾病 

分 类 号：R392.11[医药卫生—免疫学]