MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE  

作　　者：邓英杰 陈学思 

机构地区：[1]School of Pharmacy,Shenyang Pharmaceutical University [2]State Key Laboratory of Polymer Chemistry and Physics,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences

出　　处：《Chinese Journal of Polymer Science》2011年第2期173-179,共7页高分子科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.20274048,50373043);Chinese Academy of Sciences(No.KJCX2-SW-H07)

摘　　要：Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly（ethylene glycol） blocked poly（L-lactide）.Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry.According to in vitro drug release investigation by high performance liquid chromatography,it was found that fibers with 10%,20%and 30%drug entrapped respect to polymer（mass ratio） presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K.The reason may be that fibers with 10%drug entrapped was more easily affected by enzyme while,to some degree,magnolol in fibers with 20% and 30%entrapped prevented polymer from being degraded by enzyme.Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly（ethylene glycol） blocked poly（L-lactide）.Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry.According to in vitro drug release investigation by high performance liquid chromatography,it was found that fibers with 10%,20%and 30%drug entrapped respect to polymer（mass ratio） presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K.The reason may be that fibers with 10%drug entrapped was more easily affected by enzyme while,to some degree,magnolol in fibers with 20% and 30%entrapped prevented polymer from being degraded by enzyme.

关 键 词：Medicated fiber Electrospinning Drug release Poly（ethylene glycol） POLYLACTIDE MAGNOLOL Proteinase K 

分 类 号：O631.3[理学—高分子化学]