乌司他丁对法洛氏四联症根治患者体外循环期间全身炎症反应的影响  

作　　者：王韬甫[1,2] 李新丹[1,2] 宋志冰[1,2] 乔辉[1,2] 

机构地区：[1]郑州人民医院麻醉科,河南郑州450053 [2]河南省科学技术信息研究院,河南郑州450003

出　　处：《中国中医药咨讯》2011年第3期139-141,共3页

摘　　要：目的观察乌司他丁对法洛氏四联症根治术患者体外循环期间全身炎性反应的影响。方法拟施法洛氏四联症根治术患者40例，性别不限，体重12—47kg，年龄2-18岁，ASA II—III级，用随机、双盲方法分为2组（n=20）：对照组（c组）和乌司他丁组（u组）。u组于麻醉后静脉恒速注射乌司他丁8000U／kg，CPB开始前输完，然后以4000u／（kg．h）的速率持续静脉输注至CPB结束，c组以等容量生理盐水替代乌司他丁。于CPB前5min（T1）、CPB开始后10min（T2）、CPB结束后30min（T3）、60min（T4）时测定血浆白细胞介素6（IL-6）、IL-8、IL-10及肿瘤坏死因子a（TNFa）的浓度。结果与C组比较，u组CPB期间和CPB结束后血浆IL-6、IL8和TNF-a的浓度降低，IL-10浓度升高（P〈0．05或0．01）；与T1比较T2．3时两组血浆IL-6、IL-8、IL-10、TNF—a的浓度升高（P〈0．01）。结论乌司他丁可减低法洛氏四联症根治术患者CPB期间促炎．抗炎反应失衡，减轻全身炎性反应。Objective ulinastatin of tetralogy of Fallot during radical surgery with cardiopulmonary bypass systemic inflammatory response. Method scheduled for tetralogy of Fallot patients, radical surgery 40 patients, either sex, weighing 12-47 kg, ages 2-18 years old, ASAII or III, with randomized, double-blind method is divided into 2 groups （ n = 20）： control group （c group） and the UTI group （u） group, u group constant intravenous injection after anesthesia Ulinastatin 8000U/kg, CPB before the start of losers, then 4000u / （kg.h） the rate of continuous infusion to the end of CPB, c group such as saline Alternative UTI. In the CPB before 15 min （T1）, CPB after the start of 10 min （T2）, CPB after 30 min （T3）, 60 min （T4） in blood plasma interleukin-6 （IL-6）, IL-8, IL -10 and tumor necrosis factor a （TNFa） concentrations. Results Compared with the C, u CPB group during and after CPB in plasma IL-6, IL8, and reduce the concentration of TNF-a, IL-10 concentration （P 〈0.05 or 0.01）; compared with T1 T2.3 when the two groups in plasma IL-6, IL-8, IL-10, TNF-a concentrations increased （P 〈0.01）. Conclusion Ulinastatin reduce tetralogy of Fallot patients with radical pro-inflammatory during CPB. Anti-inflammatory response imbalance, reduce the systemic inflammatory response

关 键 词：胰蛋白酶抑制剂 全身炎症反应综合征 法洛氏四联症 心肺转流术 

分 类 号：R654.2[医药卫生—外科学]