Behavior toxicity to Caenorhabditis elegans transferred to the progeny after exposure to sulfamethoxazole at environmentally relevant concentrations  

作　　者：Zhenyang Yu 

机构地区：[1]Key Laboratory of Yangtze River Water Environment, Ministry of Education, Shanghai 200092, China [2]College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China

出　　处：《Journal of Environmental Sciences》2011年第2期294-300,共7页环境科学学报（英文版）

基　　金：supported by the Key Project of Shanghai Natural Science Foundation(No. 08JC1418900);the National Natural Science Foundation of China(No.20777055);the National Major Science and Technology Project:Water Pollution Control and Management(No. 2008ZX07421-001)

摘　　要：Sulfamethoxazole （SMX） is one of the most common detected antibiotics in the environment. In order to study whether SMX can affect behavior and growth and whether these effects could be transferred to the progeny, Caenorhabditis elegans was exposed at environmentally relevant concentrations for 24, 48, 72 and 96 hr, respectively. After exposure, the exposed parent generation （P0） was measured for behavior and growth indicators, which were presented as percentage of controls （POC）. Then their corresponding unexposed progeny （F1） was separated and measured for the same indicators. The lowest POC for P0 after 96 hr-exposure at 100 mg/L were 37.8%, 12.7%, 45.8% and 70.l% for body bending frequency （BBF）, reversal movement （RM）, Omega turns （OT） and body length （BL）, respectively. And F1 suffered defects with the lowest POC as 55.8%, 24.1%, 48.5% and 60.7% for BBF, RM, OT and BL, respectively. Defects in both P0 and F1 showed a time- and concentration-dependent fashion and behavior indicators showed better sensitivity than growth indicator. The observed effects on F1 demonstrated the transferable properties of SMX. Defects of SMX at environmental concentrations suggested that it is necessary to perform further systematical studies on its ecological risk in actual conditions.Sulfamethoxazole （SMX） is one of the most common detected antibiotics in the environment. In order to study whether SMX can affect behavior and growth and whether these effects could be transferred to the progeny, Caenorhabditis elegans was exposed at environmentally relevant concentrations for 24, 48, 72 and 96 hr, respectively. After exposure, the exposed parent generation （P0） was measured for behavior and growth indicators, which were presented as percentage of controls （POC）. Then their corresponding unexposed progeny （F1） was separated and measured for the same indicators. The lowest POC for P0 after 96 hr-exposure at 100 mg/L were 37.8%, 12.7%, 45.8% and 70.l% for body bending frequency （BBF）, reversal movement （RM）, Omega turns （OT） and body length （BL）, respectively. And F1 suffered defects with the lowest POC as 55.8%, 24.1%, 48.5% and 60.7% for BBF, RM, OT and BL, respectively. Defects in both P0 and F1 showed a time- and concentration-dependent fashion and behavior indicators showed better sensitivity than growth indicator. The observed effects on F1 demonstrated the transferable properties of SMX. Defects of SMX at environmental concentrations suggested that it is necessary to perform further systematical studies on its ecological risk in actual conditions.

关 键 词：SULFAMETHOXAZOLE transferable property Caenorhabditis elegans environmental concentration 

分 类 号：S831.2[农业科学—畜牧学] TQ463.53[农业科学—畜牧兽医]