系统性红斑狼疮相关基因与微卫星技术  

Systemic lupus erythematosus relative genes and microsatellite technology(Review)

作　　者：陈荣威[1] 李晓岚[1] 

机构地区：[1]昆明医学院第二附属医院皮肤性病/风湿免疫科,云南650101

出　　处：《中国优生与遗传杂志》2011年第2期1-3,122,共4页Chinese Journal of Birth Health & Heredity

摘　　要：系统性红斑狼疮(SLE)是自身免疫性疾病原型,为多基因遗传病,其致病基因或易感基因的定位一直是近年来的研究热点。微卫星是近年大力开发的一种遗传标记。微卫星作为第二代分子遗传标记,已经在很多领域得到广泛应用。本文介绍了微卫星技术在人和鼠系统性红斑狼疮相关基因研究中的应用,为其他系统性红斑狼疮相关基因研究提供新的方法和思路。Systemic lupus erythematosus（SLE）is the prototype systemic autoimmune disease.It is a disease of multifactorial inheritance.Localizing of virulence gene or susceptibility gene is the research hotspot for the past few years.Microsatellite is a kind of genetic marker explored recently.As one of the second generation of molecular genetic markers,microsatellites have a wide range of applications which previously were difficult to address experimentally.This review has introduced the application of study on relative genes for human and mice SLE with microsatellite technology.The author provided a new thinking and method for research on other relative genes of SLE.

关 键 词：微卫星技术 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]