乙肝病毒宫内感染新生儿联合免疫效果观察  

Observation on the effect of combined immunization in neonates with intrauterine infection of hepatitis B virus

作　　者：王芳[1] 张海涛[2] 乔云波[3] 庄东明[1] 于爱莲[4] 

机构地区：[1]泰山医学院公共卫生学院,山东泰安271000 [2]泰安市妇幼保健院 [3]济南市妇幼保健院 [4]泰山医学院病原学教研室

出　　处：《中国妇幼保健》2011年第3期369-371,共3页Maternal and Child Health Care of China

基　　金：山东省计生委资助项目〔2006-6〕

摘　　要：目的:了解乙肝病毒宫内感染新生儿主被动联合免疫的免疫成功率和失败率,评价主被动联合免疫的效果。方法:选取乙肝病毒携带孕妇分娩的宫内感染新生儿54例,乙肝病毒携带孕妇分娩的非宫内感染新生儿134例和正常孕妇分娩的新生儿164例,观察各组的免疫成功率和免疫失败率。结果:乙肝病毒携带孕妇分娩的非宫内感染的婴幼儿,免疫成功率为77.05%,免疫失败率为22.95%;正常孕妇分娩的婴幼儿,免疫成功率为88.67%,免疫失败率为11.33%;乙肝病毒携带孕妇分娩的婴幼儿,免疫成功率为59.18%,免疫失败率为40.82%。结论:主被动联合免疫对乙肝病毒宫内感染新生儿起到了积极的保护作用,但仍存在较高的失败率。Objective：To understand the success rate and failure rate of active-passive combined immunization in neonates with intrauterine infection of hepatitis B virus（HBV）,evaluate the effect of combined immunization.Methods：54 neonates with intrauterine infection of HBV whose mothers were HBV carriers,134 neonates without intrauterine infection of HBV whose mothers were HBV carriers and 164 normal neonates whose mothers were healthy pregnant women were selected,the success rates and failure rates in the three groups were observed.Results：The success rates and failure rates of active-passive combined immunization were 77.05% and 22.95% in 134 neonates without intrauterine infection of HBV,88.67% and 11.33% in 164 normal neonates,59.18% and 40.82% in 54 neonates with intrauterine infection of HBV,respectively.Conclusion：Active-passive combined immunization can protect the neonates with intrauterine infection of HBV actively,but the failure rate keeps high.

关 键 词：乙肝病毒 乙肝疫苗 乙肝免疫球蛋白 主被动免疫 宫内感染 

分 类 号：R715.8[医药卫生—妇产科学]