江门地区女性生殖道人乳头瘤病毒感染的感染状况  

Infection status of human papillomavirus infection of female genital tract in Jiangmen area

作　　者：陆少颜[1] 伍淑瑶[1] 梁小萍[1] 陈泳言[1] 谭忠伟[1] 彭彧[1] 严秋林[1] 陈敏[1] 

机构地区：[1]广东省江门市妇幼保健院,529000

出　　处：《中国妇幼保健》2011年第3期387-388,共2页Maternal and Child Health Care of China

基　　金：江门市科技计划项目〔200976〕

摘　　要：目的：探讨江门地区女性生殖道人乳头瘤病毒感染以及HPV基因亚型的分布状况。方法：2009年1月2010年3月采取HPV导流杂交基因芯片技术对2000名志愿者进行宫颈癌筛查,并对HPV亚型感染、多重感染及感染者年龄分布情况进行分析。结果：2000例女性HPV感染422例,平均年龄为（35.6±9.9）岁,HPV感染率为21.1%（422/2000）;高危型HPV前五位排列分别为HPV16、52、58、33、53,低危型HPV前三位排列分别为HPV11、6、44;单重感染占79.3%、多重感染占20.7%;从6个年龄组中HPV感染率前三位排列是6175岁、1620岁、2130岁年龄段,分别是43.6%、30.5%、24.0%,她们之间存在明显的差异（P〈0.01）。结论：江门地区女性生殖道人乳头瘤病毒感染最常见的亚型为HPV16,HPV基因亚型的分布存在地方性的差异。Objective：To explore the status of human papillomavirus（HPV） infection of female genital tract in Jiangmen area and the distribution of HPV gene subtypes.Methods：HPV diversion hybridization gene chip technology was used in the study,2 000 volunteers received cervical cancer screening from January 2009 to March 2010;the distribution status of HPV subtypes infection,multiple infection and age of infected cases were analyzed.Results：Among 2 000 women,422 women were infected by HPV,the average age was（35.6 ± 9.9） years,the infection rate of HPV was 21.1%（422/2 000）;the first five high risk HPV subtypes were HPV16,52,58,33,53;the first three low risk HPV subtypes were HPV11,6,44;the proportions of single infection and multiple infection were 79.3% and 20.7%,respectively;the first three age groups of HPV infection were 61～75 years old group（43.6%）,16～20 years old group（30.5%） and 21～30 years old group（24.0%）,there was significant difference（P〈0.01）.Conclusion：The most common subtype of HPV infection of female genital tract in Jiangmen area is HPV16,the distribution of HPV gene subtypes has local difference.

关 键 词：女性生殖道 人类乳头瘤病毒 感染状况 

分 类 号：R711.3[医药卫生—妇产科学]