大剂量地塞米松联合小剂量利妥昔单抗治疗难治性免疫性血小板减少性紫癜  

High dose of dexamethasone combined with low dose of rituximab in treatment of refractory immunologic thrombocytopenia

作　　者：金旸缙[1] 夏程美[1] 赵敏蕾[1] 陈延杰[1] 陈玉[1] 刘伟红[1] 裘红英[1] 李琳洁[1] 

机构地区：[1]丽水市中心医院血液科,浙江丽水323000

出　　处：《临床血液学杂志》2011年第1期39-41,共3页Journal of Clinical Hematology

摘　　要：目的:观察静脉滴注大剂量地塞米松联合小剂量利妥昔单抗治疗难治性免疫性血小板减少性紫癜(ITP)的疗效和不良反应。方法:对8例难治性免疫性血小板减少性紫癜患者采用静脉滴注大剂量地塞米松40mg/d,连续4d。利妥昔单抗剂量为100mg/w,连续4周。结果:显效3例,良效3例,进步1例,无效1例。无严重不良反应。结论:大剂量地塞米松联合小剂量利妥昔单抗治疗难治性ITP有较好的疗效,不良反应小,可作为难治性ITP治疗的有效手段之一。Objective：To observe the clinical effects of high dose of dexamethasone combined with low dose of rituximab in treatment of refractory immunologic thrombocytopenia （ITP） and its side effects.Method：Eight patients with refractory ITP given with high dose of dexamethasone 40 mg/d through intravenous drip successive 4 days,and given with low dose of rituximab 100 mg/w through intravenous drip successive 4 weeks.Result：Show results 3 examples,good effect 3 examples,progress 1 examples,invalid 1 examples. There was no risk of adverse events.Conclusion：The high dose of dexamethasone combined with low dose of rituximab has striking therapeutic effect in treating refractory ITP with little side effect and can be used as an effective way of treatment.

关 键 词：紫癜 血小板减少性 免疫性 地塞米松 利妥昔单抗 

分 类 号：R558[医药卫生—血液循环系统疾病]