多精受精对体外受精-胚胎移植临床结局的影响  

Effects of polyspermy on the clinical outcomes of in vitro fertilization and embryo transfer

作　　者：秦小娥[1] 张波[1] 冯贵雪[1] 周红[1] 舒金辉[1] 周莉[1] 刘茵[1] 甘贤优[1] 谭舒尹[1] 姚妮[1] 

机构地区：[1]广西壮族自治区妇幼保健院生殖中心,南宁530003

出　　处：《中国优生与遗传杂志》2011年第1期108-109,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨多精受精对体外受精-胚胎移植(IVF-ET)临床结局的影响。方法回顾性分析在我院行IVF-ET治疗的资料,根据多精受精率分为四组:0组;>0,≤10%组;>10%,≤20%组;>20%组,比较各组的受精率、第三天的可用胚胎率、种植率以及妊娠率。结果四组的胚胎种植率及临床妊娠率均无显著性差异(29.91%vs35.85%,29.91%vs33.83%,29.91%vs32.43%,P>0.05;47.50%vs48.71%,47.50%vs53.13%,47.50%vs45.40%P>0.05).。但当多精受精率>10%,正常受精率显著下降(72.37%vs68.49%,72.37%vs55.42%;P<0.001);多精受精率>20%,可用胚胎率显著低于≤10%组(52.25%v48.63%,P=0.0472)。结论多精受精对胚胎移植率和临床妊娠率没有显著影响,但过高的多精受精率会降低可用胚胎率。Objective： To determine the influence of polyspermy on the clinical outcomes of in vitro fertilization and embryo transfer （IVF-ET）.Methods： A total of 783 cycles undergoing IVF treatment were involved in this retrospective study.Acoording to the polyspermy rate,patients were devided into four groups as follows： 0; 0,≤10% , 10% ,≤20% ; 20%.Then the fertilization rate,the rate of embryo suitable to transfer,implantation rate and pregnancy rate were compared.Results： No differences were observed in implantation rate and pregnancy rate among the four groups （29.91% vs35.85% ,29.91% vs 33.83% ,29.91% vs 32.43% ,P 〉0.05;47.50% vs 48.71% ,47.50% vs 53.13,47.50% vs 45.40%.P 〉0.05）.However,the fertilization rate was significantly decreased when the polyspermy rate was over 10% （72.37% vs 68.49% ,72.37% vs 55.42% ,P〈 0.05）.And the rate of embryo suitable to transfer in polyspermy rate 20% group was significant lower than ≤10% group （52.25% vs 48.63% ,P〈 0.05）.Conclusion： Polyspermy rate in IVF-ET was no significant effects on the implantation rate and pregnancy rate,while High polyspermy rate would decrease the rate of embryos suitable to transfer.

关 键 词：多精受精 体外受精-胚胎移植 临床妊娠结局 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]