夫精宫腔内人工授精影响因素与临床妊娠率关系分析  

Analysis the influencing factors on the clinical pregnancy rate of intrauterine insemination with husband sperm

作　　者：周军英[1] 朱立华[1] 孙秀芬[1] 周瑾[1] 许玉刚[1] 欧建平[2] 

机构地区：[1]山东省聊城市第二人民医院生殖医学科,475000 [2]中山大学附属第一医院生殖医学中心

出　　处：《中国优生与遗传杂志》2011年第1期119-121,100,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨宫腔内人工授精(IUI)影响因素与临床妊娠率的关系,以提高IUI治疗的临床效果。方法对252个IUI治疗周期的159例患者的年龄、不孕年限、促排卵方案、人工授精时机、IUI治疗周期数、不孕原因与临床妊娠率的关系进行分析。结果促排卵周期显著提高临床妊娠率(P<0.05);小于等于30岁组临床妊娠率显著高于30以上组(P<0.05);随不孕年限延长临床妊娠率降低、单次排卵前、单次排卵后和双次授精妊娠率无统计学差异;IUI治疗周期数以3个周期为宜、不孕原因与临床妊娠率有关但无统计学差异。结论促排卵方案和年龄是影响临床妊娠率的主要因素。Objective： To investigate the influencing factors of intrauterine insemination （IUI） in order to improve the clinical outcome of IUI treatment.Methods： 159 couples in 252 cycles who underwent IUI treatment were collected.The correlation between pregnancy rate and the following factors were analyzed,such as the stimulation protocols,age of women,the duration of infertility,timing of intrauterine insemination,treatment cycles of IUI,causes of infertility.Results： IUI treatment with ovarian stimulation significantly increased clinical pregnancy rate （P 〈0.05）.The pregnancy rate was significantly higher in younger women group （less than 30 years old） than those women whose were more than 30 years old （P 〈0.05）.With the increase in duration of infertility,the pregnancy rate was decreased.There was no significant difference in the pregnancy rate between single insemination and twice inseminations before and/ after ovulation.3 cycles was suitable for IUI treatment.There was no significant difference in the pregnancy rate between primary and secondary infertility,the same to reasons of infertility.Conclusion： The protocols of ovarian stimulation and age of women were two major influencing factors for clinical pregnancy rate in IUI treatment.

关 键 词：人工授精 临床妊娠率 影响因素 

分 类 号：R714.8[医药卫生—妇产科学]