纳洛酮提高肝移植大鼠术后存活率的研究  

Influence of Naloxone on the Survival Rate Following Orthotopic Liver Transplantation in Rats

作　　者：徐贤绸[1] 陈崇别 施书强 杨潇[2] 荆河[2] 林胜璋[2] 

机构地区：[1]浙江省平阳县人民医院普外科,浙江平阳325400 [2]温州医学院附属第二医院肝胆外科,浙江温州325027

出　　处：《中国现代医生》2011年第3期9-10,共2页China Modern Doctor

摘　　要：目的观察纳洛酮对大鼠全肝及部分肝移植术后成活率的影响。方法建立全肝原位肝移植大鼠模型60只,随机分为A组和B组;部分肝移植大鼠模型60只,随机分为C组和D组。A组和C组模型大鼠术后(关腹前)腹腔内滴注纳洛酮0.2mg/kg,观察每组大鼠术后苏醒时间及1、3、7、15d的存活率。结果 A组(与B组比较)和C组(与D组比较)大鼠的苏醒时间均明显减少,术后3、7、15d的成活率均明显提高。结论纳洛酮可有效提高全肝及部分肝移植大鼠肝移植大鼠术后的成活率。Objective To investigate the influence of naloxone on the survival rate following total and partial orthotopic liver transplantation in rats. Methods Sixty total orthotopic liver transplantation （OLT） of rats were divided into group A and roup B randomly and Sixty partial orthotopic liver transplantation（POLT） of rats were divided into group C and group D randomly. After the operation of transplantation, group A,C received naloxone （0.2mg/kg） as an extra treatment. The awake time and the survival rate of all groups were evaluated respectively. Results The awake time of group A（contrast to group B） and group C（contrast to group D） were shorter significandy. The survival rates of group A and group C at the day of 3rd .7th .15th after operation were higher significantly. Conclusion Naloxone can enhance the survival rate following total and partial orthotopic liver transplantation in rats.

关 键 词：纳洛酮 肝移植 大鼠 存活率 

分 类 号：R657.3[医药卫生—外科学]