短化方案治疗肺结核的毒副反应临床观察  

Clinical observation of the toxic and adverse reaction of the short--course chemotherapy in treating pulmonary tuberculosis

作　　者：赖光明 

机构地区：[1]四川省罗江县疾病预防控制中心,618500

出　　处：《健康必读（下）》2011年第2期36-37,共2页

摘　　要：目的：为探索短化方案在治疗肺结核病人中毒副作用发生的频度、强度。方法：对805倒肺结核病人采用全球基金结核控制项目统一短化方案治疗。结果：毒副反应发生率85％，其中胃肠道反应占40．2％；因毒副反应严重而终止治疗占1．3％。约80％的毒副反应发生在用药2个月内。结论：认为毒副反应发生与化疗方案中药物组成多、剂量偏大、空腹服药及个体差井等有关。Objective： To study the frequency and intensity of the toxic and adverse reaction of the short--course chemotherapy in treating the tuberculosis patients. Methods：Use the united short--course chemotherapy with the global fund of TB control project for 805 tuberculosis patients . Results： The response rates of the toxic and adverse reaction was 85%, and the response rates of the gastrointestinal was 40.2% ; the rates of the patients were interrupted because of the severe side effects were 1.3%. About 80% of the side effects happened in 2 months. Conclusion：The occurring of the side effects are associated with complex ingredients of the drug in the chemotherapeutic project, over dose, taking pills on an empty stomach and individ- ual difference.

关 键 词：短化 肺结核 毒副反应 

分 类 号：R521.05[医药卫生—内科学]