大黄牡丹汤加减对腹膜粘连大鼠t-PA、PAI变化的调节作用  

Effect of "Dahuang Mudan(大黄牡丹)Decoction" Treatment on Plasma Tissue-type-Plasminogen Activator and Pasminogen Activator Inhibitor Levels in Rats with Peritoneal Adhesion

作　　者：董迎[1] 崔华雷[1] 王晓晔[1] 董亮[1] 

机构地区：[1]天津市儿童医院微创外科,天津300074

出　　处：《中国中西医结合外科杂志》2011年第1期69-72,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:观察大黄牡丹汤加减对腹膜粘连大鼠血浆中t-PA、PAI变化的影响。方法:采用开腹钳夹肠管法制作腹膜粘连大鼠模型,检测其血浆中组织纤维蛋白溶酶原激活剂(t-PA)、纤溶酶原激活剂抑制因子(PAI)含量,观察腹膜粘连程度。结果:大黄牡丹汤加减可以增加腹膜粘连大鼠血浆t-PA含量,降低血浆PAI含量,使腹膜粘连减轻。结论:大黄牡丹汤可以减轻大鼠腹膜粘连程度。Objective To observe the effect of Dahuang Mudan（大黄牡丹）Decoction on plasma tissue-type plasminogen activator （t-PA） and plasminogen activator inhibitor （PAI） levels in rats with peritoneal adhesion. Methods Adopting the method of forceps clip intestinal canal through laparotomy, rats models with peritoneal adhesion were made. To observe peritoneal adhesion grade, plasma t-PA and PAI levels were measured before and after Dahuang Mudanpi Decoction treatment. Results Plasma t-PA level was elevated while PAI level reduced after Dahuang Mudanpi Decoction treatment. Conclusion Dahuang Mudanpi Decoction treatment may prevent peritoneal adhesion in rats by affecting the excretion ratio of t-PA and PAI levels.

关 键 词：腹膜粘连 大黄牡丹汤 t-PA(组织纤维蛋白溶酶原激活剂) PA(I纤溶酶原激活剂抑制因子) 

分 类 号：R656.4[医药卫生—外科学] Q95-33[医药卫生—临床医学]