不同糖耐量人群负荷后1h血糖与炎症因子TNF-α和Hs-CRP的关系  

The relation of one-hour postloade plasma glucose with inflammatory factor TNF-α and Hs-CRP in different glucose tolerance

作　　者：李颖 刘东方[2] 刘军[2] 

机构地区：[1]重庆市红十字会医院内科,重庆400025 [2]重庆医科大学附属第二医院内分泌科,重庆400010

出　　处：《重庆医科大学学报》2011年第1期76-79,共4页Journal of Chongqing Medical University

摘　　要：目的:探讨不同糖耐量人群负荷后1h血糖与炎症因子的关系。方法:受试者分为4组:2型糖尿病(Type 2 diabetes mellitus,T2DM)组,糖耐量减低(Impaired glucose toleranceI,GT)组,正常糖耐量(Normal glucose tolerance,NGT)组;在NGT人群中取口服葡萄糖耐量试验(Oral glucose tolerance test,OGTT)糖负荷后1 h血糖(One hour plasma glucose after glucose load,1 hPG)值为8.0 mmol/L将其分为两组,OGTT1 h血糖正常组和OGTT1 h血糖高组。比较各组一般情况和超敏C反应蛋白(Supersensitivity C reactive protein,Hs-CRP)及肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)。结果:(1)从1 h血糖正常组到糖尿病组TNF-α、Hs-CRP呈上升趋势,两者在1 h血糖高组介于1 h血糖正常组和IGT组之间,其中1 h血糖高组TNF-α和Hs-CRP高于1 h血糖正常组(P<0.01和P<0.05),与IGT组差别无意义(P>0.05)。(2)1 h血糖与TNF-α、甘油三酯(Triglyeride,TG)、收缩压(Systolic blood pressure,SBP)、HsCRP呈正相关(r=0.405r;=0.388r;=0.310;均P<0.01r,=0.183;P<0.05),与高密度脂蛋白胆固醇(High-density lipoprotein cholesterol,HDL-C)呈负相关(r=-0.302;P<0.01)。其中SBP、HDL-C、TG与1 h血糖的相关性比2 h强。(3)多元线性逐步回归分析表明TG、TNF-α和SBP分别是影响1 h血糖水平的相关因素。结论:在NGT人群中当负荷后1 h血糖高于8.0 mmol/L时有炎症因子TNF-α、Hs-CRP的改变,提示可能存在慢性炎症反应,可能与IGT或糖尿病及血管病变的发生有关,在糖尿病高危患者的筛查中不能忽略这部分人群。Objective：To investigate the relationship of one-hour postloade plasma glucose with inflammatory factor in different glucose tolerance.Methods：the subjects were divided into four groups：type 2 diabetes（T2DM）,impaired glucose tolerance（IGT）,normal glucose tolerance（NGT） with 1 hPG higher than 8.0 mmol/L and normal glucose tolerance with 1 hPG lower than 8.0 mmol/L.Compare the general data and Hs-CRP、TNF-α in each group.Results：（1）TNF-α and Hs-CRP were upgraded from NGT to T2DM.The levels of TNF-α and Hs-CRP in NGT which 1 hPG exceeding 8.0 mmol/L were significantly higher than that in NGT with 1 hPG lower than 8.0 mmol/L（P0.01and P0.05） and similar with IGT（P0.05）.（2） 1 hPG were positively correlated with TNF-α、TG、 SBP、 HsCRP,（r=0.405;r=0.388;r=0.310;all P0.01,r=0.183;P0.05）and negatively with HDL-C（r=-0.302;P0.01）.The correlation of SBP、HDL-C and TG with 1 hPG were harder than that with 2 hPG.（3） Multiple regression analysis showed that TG、TNF-α and SBP were independent related factors influencing 1 hPG.Conclusion：There were the change of Hs-CRP and TNF-α of inflammatory factors and there maybe the presence of abnormal inflammatory reaction in normal glucose tolerance when 1 hPG exceed 8.0 mmol/L,which is correlated with development of IGT or diabetes and vascular lesion and we can＇t ignore them when we screen the population inclinable to diabetes.

关 键 词：负荷后1h血糖 超敏C反应蛋白 肿瘤坏死因子-Α 

分 类 号：R587.1[医药卫生—内分泌]