丘脑底核脑深部电刺激治疗苍白球联合丘脑腹中间核毁损术后的帕金森病  

Subthalamic nucleus-deep brain stimulation for Parkinson disease after combined lesioning of the unilateral globus pallidus and ventralis intermedius

作　　者：张世忠[1] 张旺明[1] 李明[1] 薛杉[1] 王建奇[1] 卢风飞[1] 姚晨[1] 

机构地区：[1]南方医科大学珠江医院神经外科广东神经外科研究所,广州510282

出　　处：《中国微侵袭神经外科杂志》2011年第2期60-62,共3页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的探讨帕金森病单侧苍白球联合丘脑腹中间核毁损术后再行对侧丘脑底核脑深部电刺激术(STN-DBS)的可行性,并对其疗效和安全性作出评价。方法应用MRI及微电极记录技术进行靶点定位,对20例单侧苍白球联合丘脑腹中间核毁损术后的帕金森病人行对侧STN-DBS,在STN-DBS术前及术后1周分别行统一帕金森评定量表(UPDRS)运动和日常生活能力量表(ADL)评分。结果 20例病人症状均有不同程度的改善,术后1周的UPDRS运动及ADL评分较术前均明显减少(P<0.05,P<0.01),无明显并发症。结论对单侧苍白球联合丘脑腹中间核毁损术后的帕金森病人,择期行对侧STN-DBS安全且可行。Objective To explore the practicability of subthalamic nucleus-deep brain stimulation（STN-DBS） in Parkinson disease patients who underwent unilateral pallidotmy and ventralis intermedius nucleus thalamotomy,and evaluate its surgical outcome and safety.Methods The target localization was identified by the combination of MRI and microelectrode recording technique.Twenty Parkinson disease patients with previous unilateral pallidotmy and ventralis intermedius nucleus thalamotomy were given contralateral STN-DBS after symptom deterioration.The unified Parkinson disease rating scale（UPDRS） motor score and activity of daily living scales（ADL） were scored before and one week after STN-DBS.Results The symptoms improved to different degrees in 20 patients and no surgical complications occurred.The UPDRS motor score and ADL score decreased significantly 1 week after the operation（P0.05,P0.01 respectively）.Conclusions For Parkinson disease patient with previous unilateral pallidotmy and ventralis intermedius nucleus thalamotomy,contralateral STN-DBS performed electively is a safe and feasible surgical therapy.

关 键 词：帕金森病 脑深部电刺激术 丘脑底核 苍白球毁损术 丘脑腹中间核 

分 类 号：R742.5[医药卫生—神经病学与精神病学]