尿酸在慢性肾病发展中的作用  

The role of serum uric acid in the progression of chronic kidney disease

作　　者：张希燃[1] 王庆文[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)解放军肾脏病研究所,南京医学硕士研究生210002

出　　处：《医学研究生学报》2011年第1期105-108,共4页Journal of Medical Postgraduates

摘　　要：高尿酸血症(hyperuricemia,HUA)是肾功能减退的表现之一,在慢性肾病(chron ic k idney d isease,CKD)的发生、发展中起着促进作用。最近的基础及临床研究进一步揭示了其在CKD进展中的作用,文中对此作一综述,旨在指导临床通过改善高尿酸水平,从而延缓CKD进展。Elevated serum uric acid is a marker for decreased renal function,and have a mechanistic role in the incidence and progression of chronic kidney disease（CKD）.Recent experimental models and clinical trials have suggested its important role in the progression of CKD.The purpose of this review is to assess the current data,aiming at proving the effect of uric acid-losing therapy in the prevention of CKD.

关 键 词：尿酸 慢性肾病 危险因素 

分 类 号：R692[医药卫生—泌尿科学]