亚临床剂量喷他佐辛联合异丙酚用于无痛取卵术的可行性研究  

Application of subclinical doses of pentazocine and propofol in painless vaginal egg retrieval

作　　者：梁芳果[1] 史永胜[1] 丁红[1] 周伟[1] 古妙宁[1] 

机构地区：[1]南方医科大学南方医院麻醉科,广东广州510515

出　　处：《南方医科大学学报》2011年第2期373-376,共4页Journal of Southern Medical University

摘　　要：目的探讨亚临床剂量喷他佐辛是否能够满足无痛取卵术的需要。方法将81例进行无痛取卵术的患者随机分组,观察组给予异丙酚1.5 mg/kg联合0.4 mg/kg喷他佐辛,对照组给予异丙酚1.5 mg/kg联合0.5 mg/kg喷他佐辛,观察平均动脉压(MAP)、心率(HR)、血氧饱和度(SPO2)、呼吸频率(RR)、意识丧失时间、苏醒时间、离院时间及并发症、术中知晓情况、不良反应等。结果喷他佐辛0.4 mg/kg组和喷他佐辛0.5 mg/kg组在检查过程中对心血管系统影响无显著性差异,在呼吸抑制方面二者具有显著性差异(0.4 mg/kg剂量组对呼吸的影响小于0.5 mg/kg剂量组);在恶心、呕吐、头晕、体位性低血压等不良反应方面无显著性差异,在意识丧失时间、苏醒时间、离院时间方面也无显著性差异,但在术中知晓、术中体动方面两组间具有显著性差异(0.4 mg/kg组患者术中知晓及术中体动较0.5 mg/kg组患者出现为多);在疼痛VAS评分方面两组间无显著性差异。结论采用0.4 mg/kg喷他佐辛联合异丙酚可以满足无痛取卵术的需要,在此剂量下,可能需要增加异丙酚的用量以增强患者镇静,减少术中知晓及术中体动。Objective To assess the feasibility of using subclinical doses of pentazocine in painless egg retrieval.Methods Eighty-one patients undergoing painless egg retrieval were randomized into the observation group and the control group to receive 0.4 mg/kg pentazocine with 1.5 mg/kg propofol and 0.5 mg/kg pentazocine with 1.5 mg/kg propofol,respectively.The mean arterial pressure（MAP）,heart rate（HR）,SPO2,respiratory rate（RR）,unconsciousness time,awake time,hospital stay,complications,consciousness during the operation and adverse effects were compared between the two groups.Results The two groups showed no significant differences in the analgesic effect,dosage of propofol,adverse effects,unconsciousness time,awake time,or hospital stay.But compared with the control group,the observation group showed greater intraoperative consciousness but with more stable respiration.Conclusion Subclinical doses of pentazocine can be used in the painless egg retrival,but the dose of propofol should be increased to reduce the body activity during the operation.

关 键 词：喷他佐辛 异丙酚 取卵术 亚临床剂量 

分 类 号：R614.3[医药卫生—麻醉学] R714.13[医药卫生—外科学]