骨质疏松症大鼠股骨中钙、磷与血清中钙、磷含量的相关性研究  

The relationship between femur and serum calcium,and phosphorus content in osteoporosis

作　　者：路宝民[1] 郭庆升[1] 

机构地区：[1]辽宁省人民医院骨外二科,沈阳110015

出　　处：《中国医师杂志》2011年第1期58-60,共3页Journal of Chinese Physician

摘　　要：目的探讨骨质疏松症的大鼠的股骨中钙、磷与血请中钙、磷含量的相关性。方法用切除双侧卵巢制作大鼠骨质疏松症动物模型，用ICP电感耦合等离子体发射光谱法测定实验组和对照组股骨中和血清中钙、磷的含量。结果实验组大鼠股骨中的钙、磷含量明显低于对照组钙、磷的含量[Ca：（218．59±10．43）m/Lvs（253．32±7．54）mg／L；P：（127．82±3．71）mg／Lvs（142．18±5．99）mg／L，P〈0．01]，而血清中的钙、磷含量明显高于对照组钙、磷的含量[Ca：（99．45±0．76）mg／LVS（97．56±0．80）mg／L；P：（67．68±1．63）mg,,／LV8（60．00±1．18）mg,／L，P〈0．01]。结论股骨中钙、磷含量的明显减少，对应血清中钙、磷含量的增加是导致骨质疏松症的病因之一。Objective To study the relationship between femur and serum calcium and phosphorus content in rat with osteoporosis. Methods We developed animal models with rat experienced bilateral oophorectomy and used inductively coupled plasma atomic emission spectrometry （ICP-AES） to determine cal- cium and phosphorus content in femur and serum of experimental group as well as control group. Results Calcium and phosphorus contents in femur in experimental group were significantly lower than that in control group [ Ca： （218.59 ± 10.43） mg/L vs （253.32 ± 7.54） mg/L; P： （ 127.82 ± 3.71 ） mg/L vs （ 142.18 ±5. 99 ） mg/L, P 〈 0. 01 ], but in serum experimental group it was significantly higher than that in control group [ Ca： （ 99.45 ± 0.76 ） mg/L vs （97.56 ± 0.80 ） mg/L; P ： （ 67.68 ± 1.63 ） mg/L vs （ 60.00 ± 1.18 ） mg/L, P 〈 0. 01 ]. Conclusion Femur calcium and phosphorus levels were significantly reduced, which was related to the increase of serum calcium and phosphorus content, and it was one of the causes of osteoporosis.

关 键 词：骨质疏松/代谢 钙/代谢 磷/代谢 股骨/代谢 血清/代谢 

分 类 号：R580[医药卫生—内分泌]