影响干粉吸入剂雾化和沉积性能的制剂因素  

The formulation factors of influencing the aerosolizing and deposition properties of dry powder inhalation

作　　者：缪旭[1] 刘旭[1] 苏健芬[1] 吴传斌[1] 

机构地区：[1]中山大学药学院广东省高校创新药物制剂工程技术研究中心,广州510006

出　　处：《国际药学研究杂志》2011年第1期42-46,共5页Journal of International Pharmaceutical Research

基　　金：广东省高校创新药物制剂工程技术研究中心(GCZX-RA0801)

摘　　要：干粉吸入剂是近年来肺部给药制剂研发的热点。随着微粉化技术不断成熟,新型给药装置日益涌现,干粉吸入剂的应用范围越来越广。本文从微粉化的药物、载体和干粉吸入器等3个方面综述了干粉吸入剂的处方组成,并重点介绍了影响药物粉末雾化和沉积性能的几个关键因素。Recently,dry powder inhalation（DPI） has become a hotspot in the research area of pulmonary drug delivery（PDD）.With the development of drug micronization technology and the emergence of innovative inhaler device,DPI has now been widely applied.This article introduces the formulation composition of DPI,which consists of micronized drug particles,carrier and inhaler device,and the formulation factors of influencing the aerosolizing and deposition properties are emphatically reviewed.

关 键 词：干粉吸入剂 处方组成 雾化 沉积 

分 类 号：R944[医药卫生—药剂学]