超声造影评价兔腹主动脉粥样斑块的初步研究  

Contrast-enhanced Ultrasound in Assessing Atheromatous Plaque of Abdominal Aorta in Rabbits Model:A Preliminary Study

作　　者：汤跃跃[1] 谢余澄[2] 黄燕玲[1] 于飞[1] 杨薇[1] 陆永萍[1] 

机构地区：[1]昆明医学院第四附属医院超声科,云南昆明650021 [2]昆明医学院第四附属医院病理科,云南昆明650021

出　　处：《昆明医学院学报》2010年第12期12-15,共4页Journal of Kunming Medical College

基　　金：云南省昆明医学院联合基金资助项目(2009CD189)

摘　　要：目的评价超声造影在实验兔腹主动脉粥样斑块诊断中的价值.方法雄性日本大耳白兔7只,高脂饮食喂养12周建立动脉粥样硬化模型.模型建立前后行腹主动脉超声造影.造影前后分别采用二维成像、视觉评分和视频密度法监测兔腹主动脉粥样斑超声成像特征并作定量分析.结果造影后血管内粥样斑回声明显增强,视频密度较造影前明显增加.结论超声造影剂可以较敏感地显示斑块动态增强过程,能提高动脉斑块诊断的敏感性.Objective To explore the diagnostic value of contrast enhanced ultrasound for atheromatous plaque of abdominal aorta in rabbits model.Methods Seven male Japanese white rabbits were fed with cholesterol diet for 12 weeks in order to establish the animal model of atherosclerosis.Contrast-enhanced Ultrasound for abdominal aorta was performed in the experimental rabbits before and after establishment of animal model.The ultraphonic imaging characteristics of atheromatous plaque of abdominal aorta in rats were mornitored by two-dimension imaging,visual scoring,and videodensity,and analyzed quantitatively before and after injection of contrast agent.Result The echo of atheromatous plaque and plaque videointensity significantly increased after injection of contrast agent after microbubbles injected.Conclusion The contrast-enhanced Ultrasound can improve the diagnostic value of atherosclerosis by enhanced the image of plaque.

关 键 词：超声造影 动脉粥样硬化 斑块 

分 类 号：R445.1[医药卫生—影像医学与核医学]