绝经后骨质疏松合并2型糖尿病患者的多因素分析  

Multivariate Analysis of Postmenopausal Osteoporosis in Patients with Type 2 Diabetes

作　　者：周友俊[1] 全兴胜[1] 何美琼[1] 张玲[1] 

机构地区：[1]昆明医学院附属延安医院核医学科,云南昆明650051

出　　处：《昆明医学院学报》2010年第12期72-75,共4页Journal of Kunming Medical College

摘　　要：目的探讨绝经后骨质疏松合并2型糖尿病(T2DM)的影响因素.方法收集绝经后骨质疏松合并2型糖尿病(T2DM)患者的糖代谢、性激素及骨密度(BMD)资料,受检者有1个或1个以上部位BMD低于2.5个标准差(T值)为骨质疏松,据此将研究对象分为两组,骨质疏松(OP)组(n=72)和正常骨密度(NOP)组(n=70),比较两组糖代谢、性激素等各项指标,使用多因素相关方法分析骨质疏松的影响因素.结果 OP组与NOP组相比,糖尿病病程、BMI、E2水平均低于NOP组,年龄、FSH、LH高于NOP组,差异有统计学意义(P<0.05);OP的发生与糖尿病患者的年龄、病程及FSH、LH、E2水平有关(P<0.05).结论绝经后骨质疏松合并糖尿病与众多因素有关,包括糖尿病病史、高龄及低E2和高FSH、LH等.Objective To investigate the influencing factors of postmenopausal osteoporosis and type 2 diabetes（T2DM）.Methods The glucose metabolism,sex hormones and bone mineral density（BMD）data of postmenopausal osteoporosis and type 2 diabetes（T2DM）patients were collected in this study.BMD of one or more parts in subjects less than 2.5 standard deviations（T value）was designate as osteoporosis.Subjects were divided into 2 groups：osteoporosis（OP）group（n=72）and normal bone mineral density（NOP）group（n=70）.Glucose metabolism,sex hormones and other indicators of patients were compared between two groups.The multivariate analysis was used to analyze the influencing factors of osteoporosis.Results Diabetes duration,BMI,E2 levels of patients in OP group were lower,and age,FSH,LH were higher than the NOP group,the difference was statistically significant（P0.05）.The incidence of OP was related with the age,duration,and FSH,LH,E2 levels of patients with diabetes（P0.05）.Conclusion Postmenopausal osteoporosis with diabetes mellitus is related with a number of risk factors,including long-term history of diabetes,advanced age,and low E2,postmenopausal osteoporosis prevention should begin as soon as possible.

关 键 词：绝经后妇女 糖尿病 骨质疏松 骨密度 

分 类 号：R587.1[医药卫生—内分泌]