Case report of a healthy,elderly man with long-term high titers for anti-acetylcholine receptor antibody without myasthenia gravis  

作　　者：Jin Jun LUO Nae J. Dun 

机构地区：[1]Department of Neurology, Temple University School of Medicine, Philadelphia, PA 19140, USA [2]Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA

出　　处：《Neural Regeneration Research》2010年第23期1832-1835,共4页中国神经再生研究（英文版）

摘　　要：Anti-acetylcholine receptor antibodies （AAR） are considered pathognomonic and pathogenetic for myasthenia gravis （MG）. AAR detection confirms clinical diagnosis of MG. However, AAR is rarely detected in patients without MG. The underlying pathophysiological mechanisms in a normal subject without MG have not been adequately addressed in previous studies. The present study reports on a case study of a healthy, elderly man with high AAR titers for 14 years. Pathophysiological mechanisms could be due to AAR heterogeneity in specificity, affinity, and multiform, and to muscle variability in response to AAR.Anti-acetylcholine receptor antibodies （AAR） are considered pathognomonic and pathogenetic for myasthenia gravis （MG）. AAR detection confirms clinical diagnosis of MG. However, AAR is rarely detected in patients without MG. The underlying pathophysiological mechanisms in a normal subject without MG have not been adequately addressed in previous studies. The present study reports on a case study of a healthy, elderly man with high AAR titers for 14 years. Pathophysiological mechanisms could be due to AAR heterogeneity in specificity, affinity, and multiform, and to muscle variability in response to AAR.

关 键 词：myasthenia gravis anti-acetylcholine receptor antibody false-positive antibody autoimmune disorder 

分 类 号：S858.292[农业科学—临床兽医学] TQ460.34[农业科学—兽医学]