儿童骨代谢指标的检查  

Measurement of bone metabolism markers in children

作　　者：廖祥鹏[1,2] 颜崇淮[2] 刘忠厚 

机构地区：[1]南京医科大学附属无锡妇幼保健院儿科,无锡214002 [2]上海交通大学医学院附属新华医院儿童保健科上海市儿科医学研究所,上海市环境与儿童健康重点实验室 [3]中国老年学学会骨质疏松委员会

出　　处：《中国骨质疏松杂志》2010年第12期956-960,共5页Chinese Journal of Osteoporosis

基　　金：无锡市科学技术局社会发展项目(CSE01017)

摘　　要：儿童骨骼是一个充满活力的器官,种族、性别、儿童发育的不同阶段、营养、疾病都影响儿童骨标测量值。骨标志物浓度能早期灵敏地反映骨代谢转换动态状况,评估骨骼代谢疾病的病理生理,以及监测治疗效果。本文综述儿童骨代谢指标检查的方法进展和参考值;包括骨代谢的直接指标如骨碱性磷酸酶、骨钙素、抗酒石酸酸性磷酸、吡啶交联物和交联断肽等,以及骨代谢间接调节指标,特别是最常检测的指标25-羟基维生素D。The bone of children is a dynamic organ. The measurements of biomarkers in children are influenced by race, gender, different stages of the child development, nutrition, and diseases. The concentrations of biomarkers can reflect the dynamic conditions of bone turnover with high sensitivity in early stage, assess the pathophysiology of bone metabolic diseases, and monitor the efficacy of treatment. This paper reviews the progress and reference values of the measurement of biomarkers of bone metabolism in children, including the direct regulation factors of bone metabolism such as bone alkaline phosphatase, osteoealcin, tartrate-resistant acid phosphatase, pyridinium cross-links and cross-linked telopeptides, and the indirect regulation factors of bone metabolism, particularly the most common evaluated marker, 25- hydroxy vitamin D.

关 键 词：骨标 儿童参考值范围 骨碱性磷酸酶 骨钙素 抗酒石酸酸性磷酸5b片断 25-羟基维生素D 

分 类 号：R681[医药卫生—骨科学]