美洛昔康对老年痴呆模型大鼠学习记忆能力及脑组织SOD,MAO-B,MDA的影响  

Effects of Meloxicam on Learning, Memory and Expression of SOD, MAO-B and MDA in Brain Tissue of Alzheimer’s Disease Model Rats

作　　者：李钟勇[1] 张鹏[1] 

机构地区：[1]四川省遂宁市中心医院,四川遂宁629000

出　　处：《中国现代应用药学》2011年第2期99-103,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的探讨美洛昔康对老年痴呆模型大鼠抗痴呆作用及其作用机制。方法采用慢性铝过负荷建立大鼠脑损伤老年痴呆动物模型,通过每天给予大鼠灌胃葡萄糖酸铝(Al3+200 mg.kg-1)溶液,每周持续5 d,连续灌胃20周建立老年痴呆大鼠动物模型;根据大鼠体重每千克给予3mg或1mg美洛昔康的比例,在大鼠灌胃给予铝后进行美洛昔康溶液灌胃。建模成功后,分别观察大鼠空间学习记忆能力、海马病理形态学变化及大鼠脑组织SOD,MAO-B活性和MDA含量。结果老年痴呆模型大鼠学习记忆能力明显下降、海马神经元损伤,而在大鼠脑组织中MDA含量及MAO-B活性则呈现明显升高趋势,同时大鼠脑组织SOD活性则显著降低。给予美洛昔康能明显改善老年痴呆模型大鼠的学习记忆能力,减轻大鼠海马神经元细胞损伤,同时使老年痴呆大鼠脑组织MDA含量明显减少,而大鼠脑组织MAO-B活性升高及SOD活性降低的趋势得到明显遏制。结论美洛昔康使老年痴呆模型大鼠学习记忆能力有明显的改善,对老年痴呆模型大鼠有显著的保护作用。OBJECTIVE To study the protective effect of meloxicam on brain damage of Alzheimer’s disease（AD） model rats. METHODS The AD model rats were established via intragastric administration of aluminum gluconate （element aluminum 200 mg·kg.1） once a day, 5 d a week for 20 weeks. Given 3 mg meloxicam per kg rat body weight and 1 mg meloxicam per kg rat after gavage given aluminum. After the success of modeling, pathomorphological changes of hippocampal neuron and the spatial learning and memory ability of rats were determined. The SOD, MAO-B activities, and the MDA contents of brain tissue in rats were measured. RESULTS The AD model rats’ spatial learning and memory ability was significantly decreased and hippocampal neuronal injury in rats. In the rat brain tissue, the MAO-B activities and the MDA content was significantly increased, at the same time, the SOD activities of rat brain tissue was significantly decreased. Meloxicam could provide significantly improvement in learning and memory function and hippocampal neuronal death of AD model rats, and could significantly reduced MDA contents in AD model rats’ brain tissue. Simultaneously, meloxicam could increase the SOD activities and decreased the MAO-B activities of AD model rats. CONCLUSION Meloxicam could noticeable prove the learning and memory function of AD rats, meloxicam has marked protective effect on AD model rats.

关 键 词：老年痴呆 美洛昔康 慢性铝过负荷 保护 

分 类 号：R965.1[医药卫生—药理学]