双歧杆菌对菌群失调大鼠血清NO及NOS的影响  

The effect of Bifidobacterium on NO and NOS in dysbacteriosis rats' serum

作　　者：郝秀春[1] 李丽秋[1] 张晓波[2] 王春敏[1] 杨景云[1] 杨利敏[3] 

机构地区：[1]佳木斯大学基础医学院微生态学研究室,黑龙江佳木斯154002 [2]佳木斯大学基础医学院病理教研室,黑龙江佳木斯154002 [3]佳木斯大学基础医学院生理教研室,黑龙江佳木斯154002

出　　处：《中国微生态学杂志》2011年第2期101-103,共3页Chinese Journal of Microecology

基　　金：国家"973"重大基础研究课题资助(2007CB513008);佳木斯大学科技重大项目资助(Sz2009-002)

摘　　要：目的观察双歧杆菌对抗生素诱导的菌群失调大鼠血清一氧化氮(Nitricoxlcle,NO)及一氧化氮合成酶(Nitric oxide synthase,NOS)的影响。方法肠道盐酸林可霉素脱污染制备肠道菌群失调大鼠。造模成功后用双歧杆菌活菌灌胃治疗,14 d后血清学检测细胞因子NO、NOS水平。结果与模型组相比,NO含量明显增多(P<0.05);NOS含量降低(P<0.05)。结论双歧杆菌活菌可能通过调节细胞因子NO、NOS含量而调整菌群失调大鼠肠道内有益菌的比例。Objective To observe the effect of Bifidobacterium on NO（nitric oxide） cnitric oxide and NOS（nitric oxide synthase） in dysbacteriosis rat′s serums.Method The rats were fed with Lincomycin Hydrochloride to cause the rats dysbacteriosis.Then the rats were treated with Bifidobacterium.The levels of NO and NOS were detected after 14 days treatment.Result Compared to the model group,the levels of NO increased significantly（P0.05）,and the levels of NOS decreased（P0.05） in the bifidobacterium group.Conclusion Bifidobacterium can effectively adjust the probiotics ratio of the rats with dysbacteriosis,and the mechanism is apparently related to alteration of the cell factor NO and NOS.

关 键 词：双歧杆菌 菌群失调 一氧化氮 一氧化氮合成酶 

分 类 号：R378.992[医药卫生—病原生物学]