重症监护病房鲍曼不动杆菌流行病学监测和分析  

Monitoring and analyzing the prevalence of Acinetobacter baumannii strains isolated from intensive care unit

作　　者：章华萍[1] 胡立群[2] 杨玉敏[1] 郭玲娇 郑丹[1] 丁刚[1] 

机构地区：[1]台州市中心医院重症医学科,浙江台州318000 [2]台州市中心医院急救医学科,浙江台州318000 [3]台州市中心医院微生物室,浙江台州318000

出　　处：《中国微生态学杂志》2011年第2期160-162,共3页Chinese Journal of Microecology

摘　　要：目的监测并分析重症监护病房(Intensive care unite,ICU)鲍曼不动杆菌(Acinetobacter baumannii,Ab)的检出率和耐药率的变化趋势,为临床防治Ab感染提供依据。方法采用细菌耐药监测软件WHONET5.4回顾分析收住综合性ICU患者送检的各种标本中Ab检出率和耐药率变化趋势。结果 2005年1月至2009年12月从ICU患者中共检出395株Ab,是ICU中最常见检出病原菌之一,占所有检出病原体的15.29%(395/2584),占G-菌的21.29%(395/1855)。Ab检出标本主要来自呼吸道,占81.01%。Ab对常用抗生素普遍耐药,相对于2005年,2009年Ab对碳氢霉烯类和头孢哌酮-舒巴坦的耐药率有显著上升(P<0.01),耐药率均已超过40%。结论 Ab是ICU最重要病原菌之一,Ab对临床常用抗菌药物普遍耐药,对碳氢霉烯类和头孢哌酮-舒巴坦的耐药率有显著上升,临床医生应引起高度重视。Objective To monitor and analyze the detection rate and the variation in drug resistance of Acinetobacter baumannii（Ab） isolated from Intensive Care Unite（ICU）,and provide the evidence for prevention and control of Ab infection.Method The data of Ab isolated from ICU were analyzed by WHONET 5.4 software.Result Between Jan 2005 and Dec 2009,there were 395 Ab strains isolated from patients in ICU.Ab was one of the most common pathogens,accounting for 15.29%（395/2584） of the total pathogens and 21.29%（395/1855） of the Gram-negative bacteria detected,with the respiratory tract being the major source（81.01%）.The antimicrobial resistance rates of Ab were very high,with the resistance rates to carbapenemas and cefoperazone/sulbactam significantly increased from 2009 to 2005（P0.01）.All resistance rates were more than 40.0% in 2009.Conclusion Ab is one of the most important microbials detected in ICU.Its resistance rates are high to all antimicrobials,with the resistance rates to carbapenemas and cefoperazone/sulbactam rising significantly,to which a great attention should be paid.

关 键 词：鲍曼不动杆菌 耐药率 重症医学科 

分 类 号：R378.99[医药卫生—病原生物学]