高原地区公路养护职工机体免疫功能的调查  

An Investigation of Immune Functions of Highway Maintainance Workers at Highland Area

作　　者：彭海[1] 吴世政[1] 周晶苹[1] 陈斌 魏玉香 

机构地区：[1]青海省人民医院,青海西宁810007 [2]青海省交通医院,青海西宁810000

出　　处：《环境与职业医学》2011年第2期96-97,共2页Journal of Environmental and Occupational Medicine

基　　金：交通部西部交通建设科技项目(编号:200631800051)

摘　　要：[目的]了解高原地区公路养护职工的体液免疫、细胞免疫功能及水平。[方法]从海拔2 800 m、3 500 m、4 300 m的公路养护区随机抽取194名公路养护工,用免疫速率散射比浊法检测其血清免疫球蛋白G、A、M含量(g/L);用流式细胞术检测其外周血T细胞亚群CD3+、CD4+、CD8+(%)。[结果]3组海拔梯度公路养护工的免疫球蛋白G、A含量差异无统计学意义(P>0.05),免疫球蛋白M差异有统计学意义(P<0.01);外周血T细胞亚群CD3+、CD4+、CD8+及CD4+/CD8+的差异有统计学意义(P<0.01)。[结论]在高原相对低氧的环境中,公路养护工人的细胞免疫、体液免疫功能有所改变。[ Objective ] To investigate the status of humoral immunity and cellular immunity in highway maintainance workers at highland area. [ Methods ] A sum of 194 highway maint/tinance workers working at different altitudes of 2 800 m, 3 500 m, and 4 300 m were randomly sampled and investigated. Their serum content of immunoglobulin （ Ig ）G, A, M （ g/L ）were determined by immune rate scatter nephelometry, and the frequencies of CD3^＋, CD4^＋ and CD8^＋ T cells in peripheral blood were detected by flow cytometry. [ Results ] Although there were no statistically significant differences in the content of IgG and IgA among the three groups （ P 〉 0.05 ）, the content of IgM had statistically significant difference （ P 〈 0.05 ） among them. The frequencies of CD3^＋, CD4^＋ and CD8^＋ T cells also showed statistically significant differences among the three groups（ P 〈 0.01 ）. [ Conclusion ] Working at high altitudes area with lower concentration of oxygen in the ambient air, abnormal humoral immunity and cellular immunity were observed in highway maintainance workers.

关 键 词：高原 免疫球蛋白 T细胞亚群 公路养护工 

分 类 号：R134.3[医药卫生—劳动卫生]