3种方案治疗小儿幽门螺旋杆菌相关胃病中焦积热症前后症状体征积分分值变化及与疗程的关系  

Changes of Symptom and Sign Integral and Relation to Course of Treatment with Three Method Treating Children's H.Pylori Gastropathy of Accumulation Symptom of Heat in Middle-Jiao

作　　者：王秀坤[1] 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215005

出　　处：《辽宁中医药大学学报》2011年第3期24-27,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项课题项目(04-05LQ02)

摘　　要：目的:观察3种方案治疗小儿幽门螺旋杆菌(H.Pylori)相关胃病中焦积热症前后症状体征积分分值变化及与疗程的关系,寻找最佳治疗方案。方法:108例H.Pylori胃病患儿按1:1:1对照原则随机分为3组:中药组、西药组和中西药组,每组各36例。中药组口服安幽颗粒(大黄、槟榔、黄连、丹参、香附、白芍);西药组口服克拉霉素、洛赛克;中西药组口服同疗程安幽颗粒加克拉霉素、洛赛克。结果:组内比较:西药组治疗1周与治疗后相比,在总症、主症积分方面均不存在统计学差异(P>0.05);而中药组、中西药组治疗1周与治疗后在主症积分、总症积分方面均存在统计学差异(P<0.01),主症积分、总症积分均有下降。组间比较:治疗1周时中药组与中西药组间在主症积分方面存在统计学差异(P<0.05),而在总症积分方面不存在统计学差异(P>0.05);治疗后主症、总症积分方面不存在统计学差异(P>0.05)(P>0.05),中药组与西药组在治疗1周时主症总症积分、治疗后主症总症积分方面均存在统计学差异(P<0.05,P<0.05,P<0.01,P<0.01)。西药组与中西药组在治疗1周时主症、总症积分,治疗后主症、总症积分方面均存在统计学差异(P<0.01,P<0.01,P<0.01,P<0.01)。结论:中西药结合治疗能明显降低小儿H.Pylori相关胃病中焦积热证主症、总症积分分值,改善临床症状;中药治疗疗效明显与疗程相关,疗程较长者疗效较好。Objective：To observe changes of symptom and sign integral and relation to course of treatment,with three method treating children’s H.pylori gastropathy of accumulation symptom of heat in middle-jiao,trying to find the best therapy method.Method：Adopting a ratio of 1：1：1,totally 108 H.pylori gastropathy chilren were randomed into three groups;the Traditional Chinese Medicine（TCM）groups（A）with AnYou granule（consisting of thubarb,root of herbaceous peong,Areca catechu L,red sage root,copitis thizome,netgrass flatsedge thizome）;the western medicine group（B）with Clarithromycin,Losec;and the combined treated group（C）with Anyou grenule and Clarithromycin,Losec in combination.The efficacy was evaluated after four weeks of treatment.Results：Comparion within group：compared one week treatment with four week,there aren’t diffience of statistical significence in total symptom and in cardinal symptom for（B）group（P〉0.05）;showing diffience of statistical significance both in cardinal symptom and total symptom for（A）groups and（C）group（P〈0.01）.Comparion among groups：（A）groups compared with（C）group,there are diffience of statistical significence in cardinal symptom（P〈0.05）and there aren’t diffience of statistical significence in total symptom for one week treatment（P〉0.05）;there aren’t diffience of statistical significance both in cardinal symptom and total symptom for four weeks（P〉0.05）.（A）groups compared with（B）group,（B）groups compared with（C）group,all showing diffience of statistical significance in one week and four week treatment both in cardinal symptom and total symptom（P〈0.01）.Conclusion：Combination of treatment of traditional chinese medicine and westren medicine can decreased symptom and sign integral evidently in children’s H.pylori gastropathy of accumulation symptom of heat in middle-jiao,and can improve the clinical symptom.The effect of traditional chinese medicine treatment relates to course of trea

关 键 词：小儿 幽门螺旋杆菌 中西医结合 中焦积热症 症状体征积分 疗程 

分 类 号：R256.3[医药卫生—中医内科学]