TLR2在类风湿性关节炎中的表达及意义  

Expression and Significance of TLR2 in Rheumatoid Arthritis

作　　者：杨丽丽[1] 米亚英[2] 王艳峰[3] 苏文[3] 

机构地区：[1]山西医科大学,山西太原030001 [2]大同大学医学院,山西大同037000 [3]山西省肿瘤医院,山西太原030001

出　　处：《中国现代医生》2011年第6期19-20,共2页China Modern Doctor

摘　　要：目的探讨TLR2在类风湿性关节炎(RA)发病中的作用。方法选取活动期RA患者29例,非活动期RA患者20例及健康对照组18例。采用流式细胞术(FCM)检测RA患者外周血单核细胞表面TLR2表达率及蛋白相对含量,结合RA常规临床检测指标,对各组进行对比研究。结果①活动期RA患者CD14+单核细胞上TLR2表达率及蛋白相对含量均显著高于非活动期和健康对照组(P<0.05),而非活动期RA患者CD14+单核细胞TLR2表达率及蛋白相对含量与健康对照相比差异无统计学意义;②外周血CD14+单核细胞上TLR2蛋白相对含量与ESR、血清CRP呈正相关(P<0.05),与RF无明显相关。结论活动期RA患者TLR2高表达,且其表达与疾病活动指标相关。TLRs信号通路可能参与了RA的病理过程,促进了外周血单核细胞的活化,进而引起炎症介质的释放。Objeeive To investigate the expression of TLR2 in rheumatoid arthritis. Methods The expression of TLR2 on CD14＋ monocytes in peripheral blood of 49 RA patients 18 healthy controls were detected by flow cytometry （FCM）. Results （1The expression rate and relative protein quantification of TLR2 on CD14＋ monocytes in active RA was significantly higher than inactive group and healthy controls （P〈0.05）; but it was no difference between inactive group and healthy controls. （2） The relative protein quantification of TLR2 was positively correlated with ESR and CRP （P〈0.05）,was no correlation with RF. Conclusion TLR2 overexpressed in active RA patients. TLRs signaling pathway may take part in the course of RA,promotc the activities of monocytes and cause to the release of inflammation mediatnrs.

关 键 词：关节炎 类风湿 单核细胞 流式细胞术 TOLL样受体 

分 类 号：R593.22[医药卫生—内科学]