联合降压治疗老年高血压疗效观察  

Effect observation of treating age patients with hypertension by multi-antihypertensive drugs

作　　者：郝德靖[1] 罗莉[2] 唐春艳[1] 曲建华[3] 

机构地区：[1]吉林大学第四临床医院(一汽总医院)急救中心,吉林长春130011 [2]吉林大学第四临床医院(一汽总医院)ICU重症监护病房,吉林长春130011 [3]吉林大学第四临床医院(一汽总医院)药剂科,吉林长春130011

出　　处：《中国医药导报》2011年第6期61-62,共2页China Medical Herald

摘　　要：目的:探讨联合应用降压药治疗老年高血压的疗效。方法:采取随机、平行分组、对照方法将患者分为三组,甲组40例,单用非洛地平缓释片(钙拮抗剂)10mg/d;乙组44例,非洛地平缓释片5mg/d+缬沙坦(血管紧张素Ⅱ受体阻滞剂ARB)80mg/d;丙组46例,非洛地平缓释片5mg/d+厄贝沙坦氢氯噻嗪150mg/d。结果:治疗8周后,丙组收缩压(SBP)和舒张压(DBP)达标率分别为60.9%和95.6%,较甲组SBP达标率(15.0%、80.0%)和乙组(9.1%、68.2%)高,差异有统计学意义(P<0.05或0.01)。甲组总不良反应发生率(27.5%,11/40)与乙组(4.5%,2/44)、丙组(8.7%,4/46)比较,P均<0.05。结论:钙拮抗剂联合ARB复合剂(ARB+小剂量利尿剂)治疗老年高血压疗效理想,且不良反应低。Objective：To discuss the effect of treating age patients with hypertension by using multi-antihypertensive drugs.Methods：The patients were divided into three groups randomly.There were 40 patients in group A;each one in this group took the single drug felodipine（calcium antagonist）10 mg/d.There were 44 patients in group B;each one in this group took the drug felodipine（calcium antagonist）5 mg/d and valsartan（angiotensinⅡreceptor blocker,ARB）80 mg/d.There were 46 patients in group C;each one in this group took the drug felodipine（calcium antagonist）5 mg/d,Irbesartan and hydrochlorothiazide 150 mg/d.Results：After the treatment of 8 weeks,the patients′ SBP in group C was lower than 140 mm Hg and DBP was lower than 90 mm Hg.The ideal rate was 60.9% and 95.6% respectively.They were higher than the rates of SBP and DBP in group A（15.0%,80.0%）and that in Group B（9.1%,68.2%）,all P0.05.Adverse reaction rates in group B（4.5%,2/44） and in group C（8.7%,4/46） were lower than that in group A（27.5%,11/40）,all P0.05.Conclusion：The effect is positive in treating age patients with hypertension by combining calcium antagonist with ARB compound（ARB plus low dose of diuretic） and the adverse reaction rate is lower.

关 键 词：高血压 抗高血压药物 厄贝沙坦 利尿药 

分 类 号：R544.1[医药卫生—心血管疾病]