还原型谷胱甘肽在治疗药物性肝病中的临床研究  

Clinical research of Reducibility glutathion in drug-induced liver disease

作　　者：覃岭[1] 陶小红[1] 李小安[2] 陆德云[2] 彭杨[2] 

机构地区：[1]重庆医科大学第一附属医院消化内科,重庆400016 [2]成都医学院第一附属医院消化内科,四川成都610500

出　　处：《四川医学》2011年第2期170-172,共3页Sichuan Medical Journal

摘　　要：目的探讨还原型谷胱甘肽在药物性肝病治疗中的临床研究。方法选择诊断为药物性肝病56例,包括中药制剂、抗结核药、化疗药、抗菌药物、抗甲亢药等导致的药物性肝病。随机分为治疗组和对照组,对照组26例,治疗组30例;对照组为多烯磷脂酰胆碱加常规治疗;治疗组在对照组的基础上加还原型谷胱甘肽治疗。结果治疗组的肝功能(AST、LDH、TBIL)恢复、症状较对照组有显著下降。治疗组总有效率为83.3%,对照组总有效率为73.1%,两组间比较差异有统计学意义(P<0.05)。结论还原型谷胱甘肽对药物性肝病的治疗是有效、安全的,并且对因氧化应急因素导致的药物性肝病疗效确切。Objective To observe the efficacy of reducibility glutathione in the treatment of drug-induced liver disease.Methods Fifty-six patients with drug-induced liver disease by Chinese drugs pharmaceutice,anti-tuberculosis drugs,chemotherapeutics,antibacterials,anti-hyperthyreosis,were randomly assigned to treatment and control group.26 patients in control group were given polyene phosphatidylcholine,while 30 patients in treatment group were treated with reducibility glutathione in combination with polyene phosphatidylcholine.Results Serum ALT,LDH and TBil levels declined significantly in both groups,The decline in serum ALT ,LDH and TBil levels was more significant in the treatment group than in the control group （P 0.05）.treatment group total effective rate was 83.3%,control group total effective rate was 73.1%.Couclusion Treat with Reducibility glutathion in drug-induced liver disease was efficacy and security,moreover therapy in drug-induced liver disease by Oxidative Stress was effective and reliable.

关 键 词：药物性肝病 还原型谷胱甘肽 氧化应激 临床研究 

分 类 号：R595.3[医药卫生—内科学]