两肾一夹肾性高血压大鼠血浆中Intermedin含量的变化  

The content changes of Intermedin on two kidney one clip in rats with renal hypertension

作　　者：梁颖[1] 黎济荣[1] 闫琳[1] 芦宁清[1] 贾月霞[1] 

机构地区：[1]宁夏医科大学,宁夏银川750004

出　　处：《宁夏医学杂志》2011年第2期97-98,96,共2页Ningxia Medical Journal

基　　金：国家自然科学基金项目(30860372)

摘　　要：目的观察两肾—夹(2-kidney1-clip,2K1C)肾性高血压大鼠血浆中Intermedin(IMD)含量的变化。方法将雄性SD大鼠随机分成正常组对照组和2K1C高血压模型组各20只,采用2K1C复制肾性高血压大鼠模型,检测心功能、左心重与体重比值(LVM/BW)。用放射免疫学方法检测IMD和血管紧张素Ⅱ(angiotensin,AngⅡ)的含量。结果与正常组相比,模型组大鼠心功能抑制,LVM/BW比值及血浆中IMD和AngⅡ的含量升高。结论两肾—夹大鼠血浆中IMD和AngⅡ含量升高,可能通过增加血循环中IMD的浓度调节血压以及对抗高AngⅡ的升血压作用。Objective To observe the content changes of Intermedin（IMD） on 2-kidney1-clip（2K1C） in rats with renal hypertension.Methods The rats was divided into normal group and renal hypertension group,and the renal hypertensive rats was copied of 2K1C;The heart function,the ratio of left ventricular mass and body weight（LVM/BW） was detected.The plasma levels IMD and angiotensinⅡ（AngⅡ） was detected by using radiation immunological methods.Results Comparing with normal group,heart function was inhibited in renal hypertension group.The content of IMD and AngⅡwas increased in blood plasma.The ratio of LVM/BW was increased.Conclusion Plasma IMD and AngⅡ levels could be increased in rats of 2K1C.

关 键 词：INTERMEDIN 两肾一夹(2K1C) 肾性高血压 血管紧张素Ⅱ 

分 类 号：R544.1[医药卫生—心血管疾病]