可溶性白细胞抗原-G在子痫前期患者的表达及意义  

The expression and significance of solved human leukocyte antigen-G in umbilical vein in pregnant women with preeclampsia

作　　者：胡进霞[1] 邓秋红[1] 温晓燕[1] 刘丽[1] 黎玉红[1] 张静[1] 

机构地区：[1]宁夏银川第一人民医院,宁夏银川750001

出　　处：《宁夏医学杂志》2011年第2期148-149,共2页Ningxia Medical Journal

基　　金：宁夏自然科学基金项目(NZ09170)

摘　　要：目的探讨可溶性人类白细胞抗原-G(SHLA-G)在子痫前期发病中的意义。方法采用酶联免疫吸附法(ELISA)测定45例子痫前期患者(轻度20例,重度25例),正常足月妊娠者49例外周静脉血及靠近胎盘处脐静脉血中SHLA-G水平。结果子痫前期外周血SHLA-G浓度(6.61±2.51)μg/L,正常组外周血SHLA-G浓度(22.03±3.12)μg/L,两组比较差异有统计学意义(P<0.05);子痫前期脐静脉血SHLA-G浓度(7.23±2.12)μg/L,正常组脐静脉血SHLA-G浓度(25.21±3.70)μg/L,差异有统计学意义(P<0.05)。子痫前期外周血SHLA-G浓度:重度(5.38±2.38)μg/L,轻度(7.17±2.41)μg/L,差异有统计学意义(P<0.05),子痫前期脐静脉血SHLA-G:重度(6.08±1.90)μg/L,轻度(8.09±1.87)μg/L,差异有统计学意义(P<0.05);子痫前期血清SHLA-G表达水平与胎儿发育无相关性(r=0.065、0.270,P=0.711、0.116);子痫前期血清SHLA-G的表达水平与子痫前期发病时间无相关性(r=0.565、0.923,P=0.586、0.380)。结论 SHLA-G水平的下降可能导致子痫前期的发病,且与子痫前期疾病的严重程度相一致,而与疾病发生早晚和胎儿宫内生长情况无相关性。Objective The expression and significance of solved human leukoeyte antigen-G（SHLA-G） in umbilical vein in pregnant women with preeclampsia will be investigated.Methods the level of exterior blood and umbilical vein SHLA-G was measured by ELISA in 45 patients with preeclampsia（20 mild,25 severe）and 49 normal pregnant women.Results the level of SHLA-G of exterior blood in preeclampsia group（6.61±2.51 ug/l） were significantly lower than that in normal pregnant group（22.03±3.12 ug/l）,（P〈0.05）.the level of SHLA-G of umbilical vein in preeclampsia group（7.23±2.12 ug/l）and in normal pregnant group（25.21±3.70） has significant difference（P〈0.05）;the level of SHLA-G of exterior blood in mild and severe group（7.17±2.41 ug/l,5.38±2.38 ug/l） has significantly difference（P〈0.05）;the level of SHLA-G of umbilical vein in mild and severe group（8.09±1.87 ug/l,6.08±1.90 ug/l） has significantly difference（P〈0.05）;There was no correlation between the level of the SHLA-G in umbilical vein in pregnant women with preeclampsia and the fetal growth（r=0.065、0.270 P=0.711、0.116 P〉0.05）;there was no correlation between the SHLA-G expression level and the contraction time of pregnant women with preeclampsia（r=0.565,0.923 P=0.586 、0.380 P〉0.05）.Conclusion the decrease of the level of SHLA-G may lead to preeclampsia.There was no correlation between serious extent、time and fetal growth in the uterus.

关 键 词：子痫前期 可溶性白细胞抗原-G 

分 类 号：R714.2[医药卫生—妇产科学]