乳疾2号治疗大鼠乳腺增生的实验研究  

Experimental study on Ruji Ⅱ in treating rats' mastoplasia

作　　者：孟祥云[1] 高雷[1] 陈进[1] 

机构地区：[1]安徽省合肥市第二人民医院药学部,安徽合肥230011

出　　处：《安徽医药》2011年第2期154-155,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的研究乳疾2号对大鼠乳腺增生病的治疗作用及其机制。方法采用手术摘除卵巢后腹腔注射苯甲酸雌二醇建立大鼠乳腺增生模型。考察给药前后大鼠乳头直径和高度的变化,测定血清性激素含量变化及血液流变学变化。结果与模型组比较,乳疾2号治疗组的大鼠乳头红肿、增大均较轻;血清雌二醇、泌乳素水平较低,孕酮水平较高;血流变各项指标明显改善。结论乳疾2号对大鼠乳腺增生病有治疗作用,其机制可能是通过调节大鼠的激素水平和改善血液流变性来实现的。Aim To study the role of Ruji Ⅱ in the treatment of the experimental mastoplasia of rat model and its mechanism.Methods The model was established by injecting estradiol benzoate into the abdominal cavity after ovariectomy.The serum contents of sex hormone and hemorheology were determined.Results Compared with model group,the symptoms of redness,swelling and tumefaction of nipples in treatment group were milder,the serum estradiol and prolactin level was lower,but the progesterone level was higher,and the hemorrheological indexes were better.Conclusion Ruji Ⅱ is effective in treating experimental mastoplasia of rat model.Its mechanism is related to adjusting the level of hormones and improving blood hemorheology in the rat.

关 键 词：乳疾2号 乳腺增生 药效学 

分 类 号：R285.5[医药卫生—中药学]