穴位敷贴联合中药治疗非酒精性脂肪性肝炎的临床研究  

Clinical research of acupuncture-point plaster therapy combining with TCM for treating non-alcoholic steatohepatitis

作　　者：李莹[1] 张玮[1] 邢练军[1] 刘洋[2] 王琍琼[1] 陈云飞[1] 王磊[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学

出　　处：《中西医结合肝病杂志》2011年第1期8-10,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：上海市教委资助项目(No.08cz021)

摘　　要：目的:观察穴位敷贴联合中药治疗肝郁脾虚型非酒精性脂肪性肝炎(NASH)的临床疗效和对患者生存质量的影响。方法:将72例肝郁脾虚型NASH患者随机分为两组。治疗组予穴位敷贴联合中药治疗12周;对照组予基础药物治疗12周。观察两组患者治疗前后症状体征、体重指数、生化指标、影像学指标和生存质量量表的变化。结果:治疗12周后,治疗组患者临床主要症状体征,包括胁肋胀痛、乏力、口苦等显著改善;体重指数明显下降,从26.04±2.03下降到23.62±2.05,与治疗前相比差异有显著性意义(P<0.05);血清生化指标ALT、γ-GT、TC、TG均较治疗前明显下降,差异具有显著性意义(P<0.01或P<0.05);对照组患者ALT、TG较治疗前明显下降,差异具有显著性意义(P<0.05);组间比较,ALT、γ-GT、TC下降水平间的差异具有显著性意义(P<0.05),治疗组优于对照组。B超好转率治疗组为61.11%,对照组为38.89%,组间差异显著(P<0.05);生理职能、躯体疼痛、活力和精神健康方面有显著性改善,与对照组比较差异有显著性意义(P<0.05)。结论:穴位敷贴联合中药治疗肝郁脾虚型NASH临床疗效好,可以提高患者生存质量,安全性好,是值得推广应用的治疗方案。Objective：To observe the the clinical efficacy with acupuncture point plaster therapy combining traditional Chinese medicine for treating liver depression and spleen deficiency type of patients with non-alcoholic steatohepatitis（NASH） and to evaluate quality of life of patients.Methods：Seventy-two patients with NASH were randomized into 2 groups.Combined treatment group with the acu-point plaster therapy and Chinese medicine treatment for 12 weeks;control group based on drug treatment for 12 weeks.Symptoms and signs such as body mass index,biochemical,imaging targets and changes in quality of life scale were observed before and after treatment.Results：After 12 weeks of treatment,the treatment group NASH clinical main symptoms and signs,including flank pain,weakness,bitter taste in the mouth were significantly improved;body mass index decreased significantly,down from 26.04 ± 2.03 to 23.62 ± 2.05,compared with the treatment,the difference was statistically significant（P0.05）;serum biochemical parameters ALT,γ-GT,TC,TG than those before treatment significantly decreased,the difference was significant（P0.01 or P0.05）;control group ALT,TG significantly decreased compared with before treatment,the difference was significant（P0.05）.Ultrasound improvement rate in treatment group was 61.11%,control group 38.89%,difference between groups was significantly（P0.05）;physiological function,bodily pain,vitality and mental health were significantly increased compared with control group and the difference was statistically significant（P0.05）.Acu-point plaster therapy and Chinese medicine treatment could improve patient quality of life.Conclusion：The acu-point plaster therapy combined with traditional Chinese treatment of NASH is clinical efficacy,and can improve patient quality of life,safety,and is worth promoting in treatment programs.

关 键 词：穴位敷贴 中药 非酒精性脂肪性肝炎 

分 类 号：R259[医药卫生—中西医结合]