L-乳酸和α-苯丙氨酸聚酯酰胺共聚物的合成表征及降解  

Synthesis,Characterization and Degradation of Poly(Ester-Amide) Derived from L-Lactic Acid and α-Phenylalanine

作　　者：魏志勇[1] 刘炼[2] 曲超[2] 许蔷[2] 刘洪泽[3] 王沛[2] 陈广义[1] 张万喜[1] 齐民[3] 

机构地区：[1]大连理工大学工业装备结构分析国家重点实验室,运载工程与力学学部汽车工程学院,辽宁大连116024 [2]大连海事大学交通与物流工程学院,辽宁大连116026 [3]大连理工大学材料科学与工程学院,辽宁大连116024

出　　处：《高分子材料科学与工程》2011年第2期1-4,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(30870633);教育部博士点基金(200801410018);中央高校基本科研业务费专项资金资助

摘　　要：以直接熔融缩聚法成功制备了L-乳酸和α-苯丙氨酸聚酯酰胺共聚物。采用红外光谱、核磁共振、凝胶色谱、差示扫描量热仪和X射线衍射等对共聚物结构和性能进行了分析测试,重点考察了投料比对产物组成、分子量及其热性能和结晶性能的影响,并对共聚物的降解性能进行了初步试验。随着α-苯丙氨酸含量增加,相应共聚物的分子量明显下降,结晶性下降直至变成无定型态,降解速率随之加快。所制备的L-乳酸和α-苯丙氨酸聚酯酰胺共聚物具有良好的降解性能。Poly（L-lactic acid-co-α-phenylalanine） copolymers,one of biodegradable poly（ester-amide）s derived from L-lactic acid and α-phenylalanine,were synthesized by direct melting copolymerization using stannous chloride and p-toluenesulfonic acid as catalyst.The structure and properties of the copolymers were measured via Fourier transform infrared spectrum（FT-IR）,nuclear magnetic resonance spectrum（1H-NMR,13C-NMR）,gel permeation in chromatography（GPC）,differential scanning calorimetry（DSC） and X-ray diffraction（XRD）.With increasing of the content of α-phenylalanine in feed,the copolymer molecular weight decrease,the diffraction and the melting peak disappear markedly,respectively.The hydrolytic degradation test indicates that the resulting copolymer has an excellent degradability;its degradation rate can be enhanced by incorporating more α-phenylalanine into copolymer chain.It is suggested that the obtained copolymer is a potential biomedical material as drug carrier.

关 键 词：聚酯酰胺 乳酸-氨基酸共聚物 苯丙氨酸 熔融缩聚 生物可降解材料 

分 类 号：TQ316.342[化学工程—高聚物工业]