新型3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲酰胺类化合物的合成  

Synthesis of novel 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid amide compounds

作　　者：张应鹏[1] 郑毅[1,2] 王俊芳[1] 窦花妮[2] 杨云裳[1] 

机构地区：[1]兰州理工大学石油化工学院,甘肃兰州730050 [2]浙江省化工研究院,浙江杭州310023

出　　处：《兰州理工大学学报》2011年第1期63-66,共4页Journal of Lanzhou University of Technology

基　　金：浙江省自然科学基金(Y3080068)

摘　　要：以2,3-二氯吡啶为起始原料经过肼解、与马来酸二乙酯成环、溴代、氧化、水解得到关键中间体3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲-1-甲酸,然后再与二氯亚砜反应生成甲酰氯,最后与各种环氨作用得到最终化合物3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲酰胺类化合物,并对最终化合物进行表征.Taking 2,3-dichloropyridine as raw material,the key intermediate 3-bromo-1-（3-chloro-2-pyridinyl）-1H-pyrazole-5-carboxylic acid was obtained by means of hydrazining,diethyl maleate,ester-bromination,oxidation,and hydrolysis first.Then the carbonyl chloride was synthesized with dichloro sulfoxide.Finally,the 3-bromo-1-（3-chloro-2-pyridinyl）-1H-pyrazole-5-carboxylic acid ammide compounds were synthesized with carbonyl chloride reacting with ring ammonia.The final compounds were characterized.

关 键 词：吡啶基吡唑羧酸 环氨 合成 

分 类 号：O622.5[理学—有机化学]